DegronMD - Q9ULL8(SHROOM4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q809R	TCGA-AA-3984	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.2222
p.Q809R	DO9002	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.2222
p.A945V	TCGA-AP-A059	UCEC	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.A945V	DO41361	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.R960M	TCGA-AP-A1DK	UCEC	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.7521
p.N810H	TCGA-AP-A1DV	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.25
p.N810H	DO43186	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.25
p.R819K	TCGA-B0-4821	KIRC	TCGA	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.2778
p.R819K	DO20131	KIRC	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.2778
p.P968H	TCGA-BG-A220	UCEC	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.2222
p.P968H	DO41784	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.2222
p.R823C	TCGA-CM-6678	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.R823C	DO10220	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.P953H	TCGA-D3-A2JB	SKCM	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.7694
p.P953H	DO47607	SKCM	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.7694
p.K958I	TCGA-D3-A3C7	SKCM	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.642
p.K958I	DO47569	SKCM	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.642
p.P804L	TCGA-DD-A4NF	LIHC	TCGA	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.0833
p.G969A	TCGA-DK-A1AC	BLCA	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1944
p.G969A	DO514	BLCA	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1944
p.H1222Q	TCGA-E2-A15S	BRCA	TCGA	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.H1222Q	DO5597	BRCA	ICGC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.G1237D	TCGA-IB-7651	PAAD	TCGA	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.2778
p.G1237D	DO46657	PAAD	ICGC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.2778
p.N810T	TCGA-RD-A7C1	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.25
p.N810T	DO50132	STAD	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.25
p.D974Y	DO8826	COAD	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.0556
p.D974Y	DO14758	HNSC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.0556
p.H1222Y	DO48215	ESCA	ICGC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.R817Q	DO13863	GBM	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation altering degron motif	0.7329
p.R817Q	DO42280	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation altering degron motif	0.7329
p.R955L	DO45441	LUSC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.8428
p.K971N	DO33776	PACA	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation substituting flanking lysine	0.25
p.S815C	DO227931	PBCA	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation altering degron motif	0.7541
p.A956T	DO52402	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation altering degron motif	0.7139
p.G968C	DO41644	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.2222
p.R817W	DO41133	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation altering degron motif	0.8634
p.S948R	DO41361	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.25
p.S1245L	SIDM00158	Glioblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00497	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00422	Hodgkin's Lymphoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00434	Plasma Cell Myeloma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00194	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00961	Ewing's Sarcoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00215	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00450	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01151	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00617	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00577	Neuroblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00535	Chondrosarcoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00781	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00441	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00553	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00362	Burkitt's Lymphoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00231	Kidney Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00590	Oral Cavity Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00581	Glioblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00002	Neuroblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00533	Pancreatic Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00040	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00492	Glioblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00235	Kidney Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00599	Osteosarcoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00487	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00251	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00375	Head and Neck Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00489	Oral Cavity Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01180	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00242	Osteosarcoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00247	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00997	Thyroid Gland Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00609	Kidney Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01019	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00324	Neuroblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00368	Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00613	Glioblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00217	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00316	Glioblastoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00554	Ovarian Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00503	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00274	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00279	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01033	Bladder Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00575	Glioma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01439	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00192	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01608	Endometrial Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01569	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01612	Endometrial Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01449	Pancreatic Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01335	Kidney Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01570	Ovarian Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01470	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01377	Ovarian Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00160	Biliary Tract Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01779	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01347	Ovarian Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00780	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01448	Head and Neck Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01658	Unknown	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01587	Bladder Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01473	Plasma Cell Myeloma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01574	Plasma Cell Myeloma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01343	Gastric Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01729	Endometrial Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.S1245L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.0556
p.D970G	SIDM00578	Neuroblastoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.D970G	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.D970G	SIDM00260	Gastric Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.D970G	SIDM00579	Neuroblastoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.D970G	SIDM00248	Gastric Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1667
p.G969R	SIDM00596	Endometrial Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1944
p.G969R	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1944
p.G969R	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1944
p.G969R	HEC-1	endometrium	COSMIC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.1944
p.A1230D	SIDM00498	Colorectal Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.2778
p.A1230D	ACH-000970	Colon/Colorectal Cancer	CCLE	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.2778
p.A1230D	SNU-C5	large intestine	COSMIC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.2778
p.I807T	SIDM00247	Gastric Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.I807T	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.I807T	ACH-000356	Gastric Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.I807T	ACH-000553	Lung Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.I807T	ACH-002042	Thyroid Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.1667
p.P941S	SIDM01133	Other Solid Cancers	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	951:964	Mutation rewiring degron network	0.0556
p.I1238V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.25
p.I1238V	ACH-000900	Lung Cancer	CCLE	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.25
p.I1238V	NCI-H23	lung	COSMIC	PPCY	ITCH	1232:1235	Mutation rewiring degron network	0.25
p.E820K	SIDM01191	Osteosarcoma	GDSC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.25
p.E820K	U-2-OS	bone	COSMIC	PMSSS	DEG_SPOP_SBC_1	813:817	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHROOM4

UniProt ID: Q9ULL8

Entrez ID: 57477

Protein name: Protein Shroom4 (Second homolog of apical protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHROOM4 in