DegronMD

Uniprot ID: Q9ULL8

Source protein: Protein Shroom4

Source gene: SHROOM4

Class: ITCH

Location: 1232:1235

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9603

ASA_SCORE: 70.775

COIL: 0.8745

CONS_SCORE: 0.428

DSS_SCORE: 0.4765

HELIX: 0.057

FCONS_SCORE: 1.242

RIG_SCORE: 0.7547

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1222Q	TCGA-E2-A15S	BRCA	TCGA	PPCY	ITCH	0.0556
p.H1222Q	DO5597	BRCA	ICGC	PPCY	ITCH	0.0556
p.G1237D	TCGA-IB-7651	PAAD	TCGA	PPCY	ITCH	0.2778
p.G1237D	DO46657	PAAD	ICGC	PPCY	ITCH	0.2778
p.H1222Y	DO48215	ESCA	ICGC	PPCY	ITCH	0.0556
p.S1245L	SIDM00158	Glioblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00497	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00422	Hodgkin's Lymphoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00434	Plasma Cell Myeloma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00194	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00961	Ewing's Sarcoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00215	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00450	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01151	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00617	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00577	Neuroblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00535	Chondrosarcoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00781	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00441	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00553	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00362	Burkitt's Lymphoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00231	Kidney Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00590	Oral Cavity Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00581	Glioblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00002	Neuroblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00533	Pancreatic Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00040	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00492	Glioblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00235	Kidney Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00599	Osteosarcoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00487	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00251	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00375	Head and Neck Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00489	Oral Cavity Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01180	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00242	Osteosarcoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00247	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00997	Thyroid Gland Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00609	Kidney Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01019	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00324	Neuroblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00368	Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00613	Glioblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00217	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00316	Glioblastoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00554	Ovarian Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00503	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00274	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00279	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01033	Bladder Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00575	Glioma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01439	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00192	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01608	Endometrial Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01569	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01612	Endometrial Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01449	Pancreatic Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01335	Kidney Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01570	Ovarian Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01470	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01377	Ovarian Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00160	Biliary Tract Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01779	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01347	Ovarian Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00780	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01448	Head and Neck Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01658	Unknown	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01587	Bladder Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01473	Plasma Cell Myeloma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01574	Plasma Cell Myeloma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01343	Gastric Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01729	Endometrial Carcinoma	GDSC	PPCY	ITCH	0.0556
p.S1245L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPCY	ITCH	0.0556
p.A1230D	SIDM00498	Colorectal Carcinoma	GDSC	PPCY	ITCH	0.2778
p.A1230D	ACH-000970	Colon/Colorectal Cancer	CCLE	PPCY	ITCH	0.2778
p.A1230D	SNU-C5	large_intestine	COSMIC	PPCY	ITCH	0.2778
p.I1238V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	0.25
p.I1238V	ACH-000900	Lung Cancer	CCLE	PPCY	ITCH	0.25
p.I1238V	NCI-H23	lung	COSMIC	PPCY	ITCH	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95996	Adenomatous polyposis coli protein 2	ITCH	1574:1577	PPCY	ITCH,NEDD4	0.9736	More...
P31785	Cytokine receptor common subunit gamma	ITCH	360:363	PPCY	ITCH,NEDD4	0.9947	More...
Q9GZS1	DNA-directed RNA polymerase I subunit RPA49	ITCH	201:204	PPCY	ITCH,NEDD4	0.994	More...
Q9H3M7	Thioredoxin-interacting protein	ITCH	331:334	PPCY	ITCH,NEDD4	0.9982	More...
Q9ULL8	Protein Shroom4	ITCH	1232:1235	PPCY	ITCH,NEDD4	0.9603	More...
Q8WV15	Transmembrane protein 255B	ITCH	307:310	PPCY	ITCH,NEDD4	0.9924	More...
Q9H425	Uncharacterized protein C1orf198	ITCH	226:229	PPCY	ITCH,NEDD4	0.9312	More...
Q8N4L1	Transmembrane protein 151A	ITCH	440:443	PPCY	ITCH,NEDD4	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPCY

Degron related mutations and impact score

Drug responses associated with SHROOM4 mutations

All proteins holding degron of PPCY