DegronMD - Q8N4L1(TMEM151A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y443F	TCGA-69-7979	LUAD	TCGA	PPCY	ITCH	440:443	Mutation altering degron motif	0.8639
p.Y443F	DO23874	LUAD	ICGC	PPCY	ITCH	440:443	Mutation altering degron motif	0.8639
p.T434M	TCGA-VQ-A91D	STAD	TCGA	PPCY	ITCH	440:443	Mutation rewiring degron network	0.1667
p.T434M	DO51783	STAD	ICGC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.1667
p.T434M	SIDM00336	Melanoma	GDSC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.1667
p.I453V	DO233179	GACA	ICGC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.0556
p.P440T	DO229259	THCA	ICGC	PPCY	ITCH	440:443	Mutation altering degron motif	0.7031
p.R430S	DO229257	THCA	ICGC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.0556
p.R430C	SIDM02072	Colorectal Carcinoma	GDSC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.0556
p.E435D	SIDM01187	Breast Carcinoma	GDSC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.1944
p.E435D	ACH-000568	Breast Cancer	CCLE	PPCY	ITCH	440:443	Mutation rewiring degron network	0.1944
p.E435D	UACC-812	breast	COSMIC	PPCY	ITCH	440:443	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons