DegronMD - Q9H3M7(TXNIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P325T	TCGA-59-2354	OV	TCGA	PPCY	ITCH	331:334	Mutation rewiring degron network	0.1667
p.P325T	DO27998	OV	ICGC	PPCY	ITCH	331:334	Mutation rewiring degron network	0.1667
p.P339A	TCGA-B0-4810	KIRC	TCGA	PPCY	ITCH	331:334	Mutation rewiring degron network	0.1944
p.P339A	DO17643	KIRC	ICGC	PPCY	ITCH	331:334	Mutation rewiring degron network	0.1944
p.E369V	TCGA-BR-8589	STAD	TCGA	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1667
p.E369V	DO47813	STAD	ICGC	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1667
p.V381M	TCGA-CK-4951	COAD	TCGA	PPTY	ITCH	375:378	Mutation rewiring degron network	0.25
p.V381M	DO10582	COAD	ICGC	PPTY	ITCH	375:378	Mutation rewiring degron network	0.25
p.R343P	TCGA-DR-A0ZM	CESC	TCGA	PPCY	ITCH	331:334	Mutation rewiring degron network	0.0833
p.R343P	DO6254	CESC	ICGC	PPCY	ITCH	331:334	Mutation rewiring degron network	0.0833
p.C384Y	TCGA-DU-6392	LGG	TCGA	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1667
p.C384Y	DO22237	LGG	ICGC	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1667
p.L386F	TCGA-EJ-A65E	PRAD	TCGA	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1111
p.L386F	DO49754	PRAD	ICGC	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1111
p.P368H	TCGA-FI-A2F4	UCEC	TCGA	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1389
p.P368H	DO43434	UCEC	ICGC	PPTY	ITCH	375:378	Mutation rewiring degron network	0.1389
p.P331S	TCGA-KQ-A41S	BLCA	TCGA	PPCY	ITCH	331:334	Mutation altering degron motif	0.6752
p.P331S	DO223593	BLCA	ICGC	PPCY	ITCH	331:334	Mutation altering degron motif	0.6752
p.M373I	DO222597	ESCA	ICGC	PPTY	ITCH	375:378	Mutation rewiring degron network	0.2778
p.T327A	DO41199	UCEC	ICGC	PPCY	ITCH	331:334	Mutation rewiring degron network	0.2222
p.R343Q	SIDM00594	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	331:334	Mutation rewiring degron network	0.0833

Kaplan plot for TXNIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TXNIP

UniProt ID: Q9H3M7

Entrez ID: 10628

Protein name: Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TXNIP in