DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPCY
Uniprot ID:
Q9H3M7
Source protein:
Thioredoxin-interacting protein
Source gene:
TXNIP
Class:
ITCH
Location:
331:334
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9982
ASA_SCORE:
51.725
COIL:
0.889
CONS_SCORE:
0.7388
DSS_SCORE:
0.6052
HELIX:
0.076
FCONS_SCORE:
1.3095
RIG_SCORE:
0.732
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P325T
TCGA-59-2354
OV
TCGA
PPCY
ITCH
0.1667
p.P325T
DO27998
OV
ICGC
PPCY
ITCH
0.1667
p.P339A
TCGA-B0-4810
KIRC
TCGA
PPCY
ITCH
0.1944
p.P339A
DO17643
KIRC
ICGC
PPCY
ITCH
0.1944
p.R343P
TCGA-DR-A0ZM
CESC
TCGA
PPCY
ITCH
0.0833
p.R343P
DO6254
CESC
ICGC
PPCY
ITCH
0.0833
p.P331S
TCGA-KQ-A41S
BLCA
TCGA
PPCY
ITCH
0.6752
p.P331S
DO223593
BLCA
ICGC
PPCY
ITCH
0.6752
p.T327A
DO41199
UCEC
ICGC
PPCY
ITCH
0.2222
p.R343Q
SIDM00594
Acute Myeloid Leukemia
GDSC
PPCY
ITCH
0.0833
Drug responses associated with TXNIP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPCY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95996
Adenomatous polyposis coli protein 2
ITCH
1574:1577
PPCY
ITCH,NEDD4
0.9736
More...
P31785
Cytokine receptor common subunit gamma
ITCH
360:363
PPCY
ITCH,NEDD4
0.9947
More...
Q9GZS1
DNA-directed RNA polymerase I subunit RPA49
ITCH
201:204
PPCY
ITCH,NEDD4
0.994
More...
Q9H3M7
Thioredoxin-interacting protein
ITCH
331:334
PPCY
ITCH,NEDD4
0.9982
More...
Q9ULL8
Protein Shroom4
ITCH
1232:1235
PPCY
ITCH,NEDD4
0.9603
More...
Q8WV15
Transmembrane protein 255B
ITCH
307:310
PPCY
ITCH,NEDD4
0.9924
More...
Q9H425
Uncharacterized protein C1orf198
ITCH
226:229
PPCY
ITCH,NEDD4
0.9312
More...
Q8N4L1
Transmembrane protein 151A
ITCH
440:443
PPCY
ITCH,NEDD4
0.9955
More...
