DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPCY
Uniprot ID:
Q9GZS1
Source protein:
DNA-directed RNA polymerase I subunit RPA49
Source gene:
POLR1E
Class:
ITCH
Location:
201:204
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.994
ASA_SCORE:
49.8
COIL:
0.93
CONS_SCORE:
0.7551
DSS_SCORE:
0.4067
HELIX:
0.0272
FCONS_SCORE:
1.1406
RIG_SCORE:
0.8049
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P201S
TCGA-22-5492
LUSC
TCGA
PPCY
ITCH
0.6752
p.P201S
DO27208
LUSC
ICGC
PPCY
ITCH
0.6752
p.P201S
SIDM01398
Melanoma
GDSC
PPCY
ITCH
0.6752
p.P201S
ACH-000661
Skin Cancer
CCLE
PPCY
ITCH
0.6752
p.A208S
TCGA-2Y-A9GT
LIHC
TCGA
PPCY
ITCH
0.2222
p.A208S
DO219506
LIHC
ICGC
PPCY
ITCH
0.2222
p.P202A
TCGA-98-8021
LUSC
TCGA
PPCY
ITCH
0.7503
p.P202A
DO27468
LUSC
ICGC
PPCY
ITCH
0.7503
p.D196A
TCGA-AJ-A5DW
UCEC
TCGA
PPCY
ITCH
0.1944
p.D196A
DO50075
UCEC
ICGC
PPCY
ITCH
0.1944
p.A207V
DO225334
BRCA
ICGC
PPCY
ITCH
0.25
p.D192H
SIDM01116
Non-Small Cell Lung Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM00969
Ovarian Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM00746
Non-Small Cell Lung Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM00690
Head and Neck Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM00311
Mesothelioma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM00849
Kidney Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM00673
Breast Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM01318
Hepatocellular Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM01677
Non-Small Cell Lung Carcinoma
GDSC
PPCY
ITCH
0.0833
p.D192H
SIDM01525
Acute Myeloid Leukemia
GDSC
PPCY
ITCH
0.0833
p.V213M
SIDM01447
Glioblastoma
GDSC
PPCY
ITCH
0.0833
Drug responses associated with POLR1E mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPCY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95996
Adenomatous polyposis coli protein 2
ITCH
1574:1577
PPCY
ITCH,NEDD4
0.9736
More...
P31785
Cytokine receptor common subunit gamma
ITCH
360:363
PPCY
ITCH,NEDD4
0.9947
More...
Q9GZS1
DNA-directed RNA polymerase I subunit RPA49
ITCH
201:204
PPCY
ITCH,NEDD4
0.994
More...
Q9H3M7
Thioredoxin-interacting protein
ITCH
331:334
PPCY
ITCH,NEDD4
0.9982
More...
Q9ULL8
Protein Shroom4
ITCH
1232:1235
PPCY
ITCH,NEDD4
0.9603
More...
Q8WV15
Transmembrane protein 255B
ITCH
307:310
PPCY
ITCH,NEDD4
0.9924
More...
Q9H425
Uncharacterized protein C1orf198
ITCH
226:229
PPCY
ITCH,NEDD4
0.9312
More...
Q8N4L1
Transmembrane protein 151A
ITCH
440:443
PPCY
ITCH,NEDD4
0.9955
More...
