DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPCY
Uniprot ID:
O95996
Source protein:
Adenomatous polyposis coli protein 2
Source gene:
APC2
Class:
ITCH
Location:
1574:1577
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9736
ASA_SCORE:
84.575
COIL:
0.928
CONS_SCORE:
0.5875
DSS_SCORE:
0.6343
HELIX:
0.0363
FCONS_SCORE:
1.0354
RIG_SCORE:
0.661
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I1569T
DO51490
PACA
ICGC
PPCY
ITCH
0.1944
p.S1587G
DO229253
THCA
ICGC
PPCY
ITCH
0.0556
p.P1566H
DO229216
THCA
ICGC
PPCY
ITCH
0.1111
Drug responses associated with APC2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPCY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95996
Adenomatous polyposis coli protein 2
ITCH
1574:1577
PPCY
ITCH,NEDD4
0.9736
More...
P31785
Cytokine receptor common subunit gamma
ITCH
360:363
PPCY
ITCH,NEDD4
0.9947
More...
Q9GZS1
DNA-directed RNA polymerase I subunit RPA49
ITCH
201:204
PPCY
ITCH,NEDD4
0.994
More...
Q9H3M7
Thioredoxin-interacting protein
ITCH
331:334
PPCY
ITCH,NEDD4
0.9982
More...
Q9ULL8
Protein Shroom4
ITCH
1232:1235
PPCY
ITCH,NEDD4
0.9603
More...
Q8WV15
Transmembrane protein 255B
ITCH
307:310
PPCY
ITCH,NEDD4
0.9924
More...
Q9H425
Uncharacterized protein C1orf198
ITCH
226:229
PPCY
ITCH,NEDD4
0.9312
More...
Q8N4L1
Transmembrane protein 151A
ITCH
440:443
PPCY
ITCH,NEDD4
0.9955
More...
