DegronMD - Q8WV15(TMEM255B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P303L	TCGA-61-2101	OV	TCGA	PPCY	ITCH	307:310	Mutation rewiring degron network	0.2222
p.P303L	TCGA-DX-A8BP	SARC	TCGA	PPCY	ITCH	307:310	Mutation rewiring degron network	0.2222
p.P303L	DO28062	OV	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.2222
p.P303L	DO220056	SARC	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.2222
p.Y324C	TCGA-85-8287	LUSC	TCGA	PPPY	ITCH	321:324	Mutation altering degron motif	0.7087
p.Y324C	DO27492	LUSC	ICGC	PPPY	ITCH	321:324	Mutation altering degron motif	0.7087
p.Y324C	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	321:324	Mutation altering degron motif	0.7087
p.Y324C	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	321:324	Mutation altering degron motif	0.7087
p.P322S	TCGA-85-8479	LUSC	TCGA	PPPY	ITCH	321:324	Mutation altering degron motif	0.6752
p.P322S	DO45443	LUSC	ICGC	PPPY	ITCH	321:324	Mutation altering degron motif	0.6752
p.P316S	TCGA-BR-A4PF	STAD	TCGA	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316S	TCGA-BR-A4PF	STAD	TCGA	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.P316S	DO228012	SKCA	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316S	DO228012	SKCA	ICGC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.P316S	DO38268	STAD	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316S	DO38268	STAD	ICGC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.P316S	SIDM00166	Other Solid Cancers	GDSC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316S	SIDM00166	Other Solid Cancers	GDSC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.P316S	ACH-000302	Endometrial/Uterine Cancer	CCLE	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316S	ACH-000302	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.F315L	TCGA-FT-A3EE	BLCA	TCGA	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1944
p.F315L	TCGA-FT-A3EE	BLCA	TCGA	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1667
p.F315L	DO720	BLCA	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1944
p.F315L	DO720	BLCA	ICGC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1667
p.A306V	DO222852	BTCA	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.3056
p.A325T	DO50090	COAD	ICGC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.3056
p.A325T	SIDM00217	Colorectal Carcinoma	GDSC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.3056
p.A325T	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	321:324	Mutation rewiring degron network	0.3056
p.A325T	SNU-1040	large intestine	COSMIC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.3056
p.P323H	DO229013	COCA	ICGC	PPPY	ITCH	321:324	Mutation altering degron motif	0.6583
p.P323H	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	321:324	Mutation altering degron motif	0.6583
p.P323H	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	321:324	Mutation altering degron motif	0.6583
p.P321T	DO27955	ORCA	ICGC	PPPY	ITCH	321:324	Mutation altering degron motif	0.7031
p.P317Q	DO35592	PBCA	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1389
p.P317Q	DO35592	PBCA	ICGC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.2222
p.A311T	DO232224	PBCA	ICGC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.3056
p.A311T	DO232224	PBCA	ICGC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.0556
p.P323R	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	321:324	Mutation altering degron motif	0.6401
p.P323R	SIDM00143	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	321:324	Mutation altering degron motif	0.6401
p.P316L	SIDM00166	Other Solid Cancers	GDSC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316L	SIDM00166	Other Solid Cancers	GDSC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.P316L	ACH-000302	Endometrial/Uterine Cancer	CCLE	PPCY	ITCH	307:310	Mutation rewiring degron network	0.1667
p.P316L	ACH-000302	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	321:324	Mutation rewiring degron network	0.1944
p.E319K	EVSA-T	breast	COSMIC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.0833
p.E319K	EVSA-T	breast	COSMIC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.2778
p.E319K	SK-MEL-2	skin	COSMIC	PPCY	ITCH	307:310	Mutation rewiring degron network	0.0833
p.E319K	SK-MEL-2	skin	COSMIC	PPPY	ITCH	321:324	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM255B

UniProt ID: Q8WV15

Entrez ID: 348013

Protein name: Transmembrane protein 255B (Protein FAM70B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM255B in