DegronMD - Q9GZS1(POLR1E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P201S	TCGA-22-5492	LUSC	TCGA	PPCY	ITCH	201:204	Mutation altering degron motif	0.6752
p.P201S	DO27208	LUSC	ICGC	PPCY	ITCH	201:204	Mutation altering degron motif	0.6752
p.P201S	SIDM01398	Melanoma	GDSC	PPCY	ITCH	201:204	Mutation altering degron motif	0.6752
p.P201S	ACH-000661	Skin Cancer	CCLE	PPCY	ITCH	201:204	Mutation altering degron motif	0.6752
p.A208S	TCGA-2Y-A9GT	LIHC	TCGA	PPCY	ITCH	201:204	Mutation rewiring degron network	0.2222
p.A208S	DO219506	LIHC	ICGC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.2222
p.P202A	TCGA-98-8021	LUSC	TCGA	PPCY	ITCH	201:204	Mutation altering degron motif	0.7503
p.P202A	DO27468	LUSC	ICGC	PPCY	ITCH	201:204	Mutation altering degron motif	0.7503
p.D196A	TCGA-AJ-A5DW	UCEC	TCGA	PPCY	ITCH	201:204	Mutation rewiring degron network	0.1944
p.D196A	DO50075	UCEC	ICGC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.1944
p.A207V	DO225334	BRCA	ICGC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.25
p.D192H	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM00969	Ovarian Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM00690	Head and Neck Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM00311	Mesothelioma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM00849	Kidney Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM00673	Breast Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM01318	Hepatocellular Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.D192H	SIDM01525	Acute Myeloid Leukemia	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.V213M	SIDM01447	Glioblastoma	GDSC	PPCY	ITCH	201:204	Mutation rewiring degron network	0.0833

Kaplan plot for POLR1E in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLR1E

UniProt ID: Q9GZS1

Entrez ID: 64425

Protein name: DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLR1E in