DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPCY
Uniprot ID:
Q9H425
Source protein:
Uncharacterized protein C1orf198
Source gene:
C1orf198
Class:
ITCH
Location:
226:229
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9312
ASA_SCORE:
79.65
COIL:
0.842
CONS_SCORE:
0.3967
DSS_SCORE:
0.6558
HELIX:
0.0903
FCONS_SCORE:
0.8452
RIG_SCORE:
0.7015
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D237Y
TCGA-37-3783
LUSC
TCGA
PPCY
ITCH
0.1111
p.S217F
TCGA-AX-A0J1
UCEC
TCGA
PPCY
ITCH
0.0833
p.P235L
TCGA-BR-4363
STAD
TCGA
PPCY
ITCH
0.1667
p.P233S
TCGA-ER-A2ND
SKCM
TCGA
PPCY
ITCH
0.2222
p.R224H
DO233872
GACA
ICGC
PPCY
ITCH
0.2778
p.R224H
DO37433
SKCM
ICGC
PPCY
ITCH
0.2778
p.S234G
DO229047
LICA
ICGC
PPCY
ITCH
0.1944
p.N219S
DO50807
LIRI
ICGC
PPCY
ITCH
0.1389
p.R226S
DO29800
OV
ICGC
PPCY
ITCH
0.7427
p.E223K
DO41903
UCEC
ICGC
PPCY
ITCH
0.3611
p.R230W
SIDM00685
Glioblastoma
GDSC
PPCY
ITCH
0.3056
Drug responses associated with C1orf198 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPCY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95996
Adenomatous polyposis coli protein 2
ITCH
1574:1577
PPCY
ITCH,NEDD4
0.9736
More...
P31785
Cytokine receptor common subunit gamma
ITCH
360:363
PPCY
ITCH,NEDD4
0.9947
More...
Q9GZS1
DNA-directed RNA polymerase I subunit RPA49
ITCH
201:204
PPCY
ITCH,NEDD4
0.994
More...
Q9H3M7
Thioredoxin-interacting protein
ITCH
331:334
PPCY
ITCH,NEDD4
0.9982
More...
Q9ULL8
Protein Shroom4
ITCH
1232:1235
PPCY
ITCH,NEDD4
0.9603
More...
Q8WV15
Transmembrane protein 255B
ITCH
307:310
PPCY
ITCH,NEDD4
0.9924
More...
Q9H425
Uncharacterized protein C1orf198
ITCH
226:229
PPCY
ITCH,NEDD4
0.9312
More...
Q8N4L1
Transmembrane protein 151A
ITCH
440:443
PPCY
ITCH,NEDD4
0.9955
More...
