DegronMD - O95996(APC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1873F	TCGA-78-7220	LUAD	TCGA	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation altering degron motif	0.6871
p.S1873F	TCGA-78-7220	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1872:1876	Mutation altering degron motif	0.6871
p.S1873F	DO24409	LUAD	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation altering degron motif	0.6871
p.S1873F	DO24409	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1872:1876	Mutation altering degron motif	0.6871
p.K1870N	TCGA-AA-A010	COAD	TCGA	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation altering degron motif	0.5806
p.R1135W	DO234336	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.0833
p.A1869V	DO233281	GACA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation altering degron motif	0.5825
p.I1569T	DO51490	PACA	ICGC	PPCY	ITCH	1574:1577	Mutation rewiring degron network	0.1944
p.Q2022R	DO218878	SKCA	ICGC	GRPALPAVF	DEG_APCC_DBOX_1	2029:2037	Mutation rewiring degron network	0.1389
p.P1864T	DO229259	THCA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation rewiring degron network	0.2222
p.P1864T	DO229259	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1872:1876	Mutation rewiring degron network	0.1111
p.Q1878P	DO229253	THCA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation rewiring degron network	0.25
p.Q1878P	DO229253	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1872:1876	Mutation rewiring degron network	0.2778
p.S1587G	DO229253	THCA	ICGC	PPCY	ITCH	1574:1577	Mutation rewiring degron network	0.0556
p.S1873P	DO229264	THCA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation altering degron motif	0.5641
p.S1873P	DO229264	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1872:1876	Mutation altering degron motif	0.5641
p.S1146N	DO229201	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7069
p.P1566H	DO229216	THCA	ICGC	PPCY	ITCH	1574:1577	Mutation rewiring degron network	0.1111
p.R1135Q	SIDM02041	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.0833
p.P1144Q	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7035
p.P1144Q	ACH-002059	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation altering degron motif	0.7035
p.A1866T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation rewiring degron network	0.2778
p.A1866T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1872:1876	Mutation rewiring degron network	0.1667
p.N1150S	SIDM00333	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.2778
p.N1150S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.2778
p.R2008G	SIDM01580	Melanoma	GDSC	FRRQLTFIK	DEG_APCC_DBOX_1	1991:1999	Mutation rewiring degron network	0.0833
p.R2008G	ACH-001550	Skin Cancer	CCLE	FRRQLTFIK	DEG_APCC_DBOX_1	1991:1999	Mutation rewiring degron network	0.0833
p.P1859S	SIDM01587	Bladder Carcinoma	GDSC	LAKTPSSS	DEG_SCF_FBW7_1	1868:1875	Mutation rewiring degron network	0.0833
p.G2003S	ACH-000691	Breast Cancer	CCLE	FRRQLTFIK	DEG_APCC_DBOX_1	1991:1999	Mutation rewiring degron network	0.2222
p.T1143M	ACH-001786	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1144:1148	Mutation rewiring degron network	0.3056

Kaplan plot for APC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APC2

UniProt ID: O95996

Entrez ID: 10297

Protein name: Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APC2 in