DegronMD

Uniprot ID: O95996

Source protein: Adenomatous polyposis coli protein 2

Source gene: APC2

Class: DEG_APCC_DBOX_1

Location: 2029:2037

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.97

ASA_SCORE: 90.8111

COIL: 0.8666

CONS_SCORE: 0.4177

DSS_SCORE: 0.4579

HELIX: 0.0837

FCONS_SCORE: 1.0315

RIG_SCORE: 0.6908

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2022R	DO218878	SKCA	ICGC	GRPALPAVF	DEG_APCC_DBOX_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95996	Adenomatous polyposis coli protein 2	DEG_APCC_DBOX_1	2029:2037	GRPALPAVF	APC,CDC20,FZR1	0.97	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons