DegronMD

Uniprot ID: O95996

Source protein: Adenomatous polyposis coli protein 2

Source gene: APC2

Class: DEG_APCC_DBOX_1

Location: 1991:1999

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8179

ASA_SCORE: 109.9889

COIL: 0.7877

CONS_SCORE: 0.5509

DSS_SCORE: 0.51

HELIX: 0.1114

FCONS_SCORE: 1.1985

RIG_SCORE: 0.7727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2008G	SIDM01580	Melanoma	GDSC	FRRQLTFIK	DEG_APCC_DBOX_1	0.0833
p.R2008G	ACH-001550	Skin Cancer	CCLE	FRRQLTFIK	DEG_APCC_DBOX_1	0.0833
p.G2003S	ACH-000691	Breast Cancer	CCLE	FRRQLTFIK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95996	Adenomatous polyposis coli protein 2	DEG_APCC_DBOX_1	1991:1999	FRRQLTFIK	APC,CDC20,FZR1	0.8179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons