DegronMD

Uniprot ID: O95996

Source protein: Adenomatous polyposis coli protein 2

Source gene: APC2

Class: DEG_SCF_FBW7_1

Location: 1868:1875

E3 ligase: FBXW7

DEGRON score: 0.988

ASA_SCORE: 103.0375

COIL: 0.9584

CONS_SCORE: 0.4755

DSS_SCORE: 0.8279

HELIX: 0.0241

FCONS_SCORE: 0.9812

RIG_SCORE: 0.5343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1873F	TCGA-78-7220	LUAD	TCGA	LAKTPSSS	DEG_SCF_FBW7_1	0.6871
p.S1873F	DO24409	LUAD	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	0.6871
p.K1870N	TCGA-AA-A010	COAD	TCGA	LAKTPSSS	DEG_SCF_FBW7_1	0.5806
p.A1869V	DO233281	GACA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	0.5825
p.P1864T	DO229259	THCA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	0.2222
p.Q1878P	DO229253	THCA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	0.25
p.S1873P	DO229264	THCA	ICGC	LAKTPSSS	DEG_SCF_FBW7_1	0.5641
p.A1866T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LAKTPSSS	DEG_SCF_FBW7_1	0.2778
p.P1859S	SIDM01587	Bladder Carcinoma	GDSC	LAKTPSSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95996	Adenomatous polyposis coli protein 2	DEG_SCF_FBW7_1	1868:1875	LAKTPSSS	FBXW7	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons