DegronMD

Uniprot ID: Q9ULL8

Source protein: Protein Shroom4

Source gene: SHROOM4

Class: DEG_ODPH_VHL_1

Location: 951:964

E3 ligase: VHL

DEGRON score: 0.7429

ASA_SCORE: 99.45

COIL: 0.944

CONS_SCORE: 0.393

DSS_SCORE: 0.5125

HELIX: 0.0319

FCONS_SCORE: 0.9602

RIG_SCORE: 0.7186

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A945V	TCGA-AP-A059	UCEC	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.A945V	DO41361	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.R960M	TCGA-AP-A1DK	UCEC	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.7521
p.P968H	TCGA-BG-A220	UCEC	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.2222
p.P968H	DO41784	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.2222
p.P953H	TCGA-D3-A2JB	SKCM	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.7694
p.P953H	DO47607	SKCM	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.7694
p.K958I	TCGA-D3-A3C7	SKCM	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.642
p.K958I	DO47569	SKCM	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.642
p.G969A	TCGA-DK-A1AC	BLCA	TCGA	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1944
p.G969A	DO514	BLCA	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1944
p.D974Y	DO8826	COAD	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.0556
p.D974Y	DO14758	HNSC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.0556
p.R955L	DO45441	LUSC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.8428
p.K971N	DO33776	PACA	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.25
p.A956T	DO52402	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.7139
p.G968C	DO41644	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.2222
p.S948R	DO41361	UCEC	ICGC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.25
p.D970G	SIDM00578	Neuroblastoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.D970G	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.D970G	SIDM00260	Gastric Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.D970G	SIDM00579	Neuroblastoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.D970G	SIDM00248	Gastric Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1667
p.G969R	SIDM00596	Endometrial Carcinoma	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1944
p.G969R	ACH-000941	Endometrial/Uterine Cancer	CCLE	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1944
p.G969R	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1944
p.G969R	HEC-1	endometrium	COSMIC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.1944
p.P941S	SIDM01133	Other Solid Cancers	GDSC	LAPGNTWKPRKLTV	DEG_ODPH_VHL_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGNTWKPRKLTV

Degron related mutations and impact score

Drug responses associated with SHROOM4 mutations

All proteins holding degron of LAPGNTWKPRKLTV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL8	Protein Shroom4	DEG_ODPH_VHL_1	951:964	LAPGNTWKPRKLTV	VHL	0.7429	More...