DegronMD

Uniprot ID: Q9ULL8

Source protein: Protein Shroom4

Source gene: SHROOM4

Class: DEG_SPOP_SBC_1

Location: 813:817

E3 ligase: SPOP

DEGRON score: 0.7425

ASA_SCORE: 83.26

COIL: 0.8812

CONS_SCORE: 0.3493

DSS_SCORE: 0.6653

HELIX: 0.104

FCONS_SCORE: 0.7831

RIG_SCORE: 0.6691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q809R	TCGA-AA-3984	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2222
p.Q809R	DO9002	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2222
p.N810H	TCGA-AP-A1DV	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.25
p.N810H	DO43186	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.25
p.R819K	TCGA-B0-4821	KIRC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.R819K	DO20131	KIRC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.R823C	TCGA-CM-6678	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1667
p.R823C	DO10220	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1667
p.P804L	TCGA-DD-A4NF	LIHC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.0833
p.N810T	TCGA-RD-A7C1	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.25
p.N810T	DO50132	STAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.25
p.R817Q	DO13863	GBM	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7329
p.R817Q	DO42280	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7329
p.S815C	DO227931	PBCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7541
p.R817W	DO41133	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.8634
p.I807T	SIDM00247	Gastric Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1667
p.I807T	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1667
p.I807T	ACH-000356	Gastric Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.1667
p.I807T	ACH-000553	Lung Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.1667
p.I807T	ACH-002042	Thyroid Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.1667
p.E820K	SIDM01191	Osteosarcoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.25
p.E820K	U-2-OS	bone	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons