DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_SPOP_SBC_1

Location: 285:289

E3 ligase: SPOP

DEGRON score: 0.9583

ASA_SCORE: 81.36

COIL: 0.879

CONS_SCORE: 0.446

DSS_SCORE: 0.5521

HELIX: 0.0582

FCONS_SCORE: 0.9723

RIG_SCORE: 0.5956

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P278L	TCGA-L5-A43M	ESCA	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1389
p.Q291E	TCGA-Q9-A6FU	ESCA	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.S287T	DO224987	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.6005
p.S288Y	DO52412	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.712
p.G291D	DO41752	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.G291S	SIDM01954	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.Q278P	SIDM00202	Ewing's Sarcoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1389
p.Q278P	EW-3	bone	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.1389
p.M286V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.6097
p.M286V	SW900	lung	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.6097
p.R275P	ACH-000659	Lung Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.0556
p.R275P	ACH-001386	Lung Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons