DegronMD - P39880(CUX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1055D	TCGA-H6-8124	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.1944
p.P1071L	TCGA-VQ-A8P2	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation blocking phosphorylation signal	0.5833
p.P1068S	DO233748	GACA	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation substituting flanking lysine	0.3333
p.D1064Y	DO228948	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation altering degron motif	0.7325
p.E1060G	DO24005	LUAD	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation altering degron motif	0.7199
p.E1069Q	DO26422	LUSC	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation blocking phosphorylation signal	0.6389
p.P1057S	DO220875	MELA	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.25
p.P1055S	DO37409	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.1944
p.P1057L	DO37408	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.25
p.S1054L	SIDM01093	Cervical Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation blocking phosphorylation signal	0.6111
p.S1054L	SIDM01061	Oral Cavity Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation blocking phosphorylation signal	0.6111
p.S1054L	SIDM01335	Kidney Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation blocking phosphorylation signal	0.6111
p.S1060N	BE-13	haematopoietic and lymphoid tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation altering degron motif	0.7069
p.K1066E	EN	endometrium	COSMIC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.2778
p.S1067F	Hs633T	soft tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation rewiring degron network	0.25
p.S1071N	BE-13	haematopoietic and lymphoid tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	1060:1064	Mutation blocking phosphorylation signal	0.5833

Kaplan plot for CUX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CUX1

UniProt ID: P39880

Entrez ID: 1523

Protein name: Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CUX1 in