DegronMD

Uniprot ID: P39880

Source protein: Homeobox protein cut-like 1

Source gene: CUX1

Class: DEG_SPOP_SBC_1

Location: 1060:1064

E3 ligase: SPOP

DEGRON score: 0.9994

ASA_SCORE: 71.54

COIL: 0.8318

CONS_SCORE: 0.3515

DSS_SCORE: 0.6221

HELIX: 0.125

FCONS_SCORE: 1.1001

RIG_SCORE: 0.54

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1055D	TCGA-H6-8124	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1944
p.P1071L	TCGA-VQ-A8P2	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.5833
p.P1068S	DO233748	GACA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.3333
p.D1064Y	DO228948	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7325
p.E1060G	DO24005	LUAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7199
p.E1069Q	DO26422	LUSC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.6389
p.P1057S	DO220875	MELA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.25
p.P1055S	DO37409	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1944
p.P1057L	DO37408	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	0.25
p.S1054L	SIDM01093	Cervical Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.6111
p.S1054L	SIDM01061	Oral Cavity Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.6111
p.S1054L	SIDM01335	Kidney Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.6111
p.S1060N	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.7069
p.K1066E	EN	endometrium	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.S1067F	Hs633T	soft_tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.25
p.S1071N	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons