DegronMD

Uniprot ID: Q9NW07

Source protein: Zinc finger protein 358

Source gene: ZNF358

Class: DEG_SPOP_SBC_1

Location: 87:91

E3 ligase: SPOP

DEGRON score: 0.9771

ASA_SCORE: 64.44

COIL: 0.846

CONS_SCORE: 0.8942

DSS_SCORE: 0.8842

HELIX: 0.073

FCONS_SCORE: 1.0961

RIG_SCORE: 0.5773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S90L	TCGA-AJ-A3EL	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.7667
p.S90L	DO41542	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7667
p.P96S	TCGA-AP-A1DK	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1944
p.P96S	DO42033	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1944
p.D93N	TCGA-CG-5719	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D93N	TCGA-EO-A22R	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D93N	TCGA-IB-7651	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D93N	DO46657	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D93N	DO36881	READ	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D93N	DO38827	STAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D93N	DO42713	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.D95N	TCGA-EA-A3HU	CESC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2222
p.D95N	TCGA-QF-A5YS	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2222
p.D95N	DO6320	CESC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2222
p.D95N	DO52426	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2222
p.P78S	DO222848	BTCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0833
p.P101S	DO23214	LINC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0556
p.P101S	DO23506	LINC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0556
p.A77P	DO51958	PRAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0556
p.D86N	SIDM00945	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.3056
p.D86N	ACH-000895	Colon/Colorectal Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.3056
p.D86N	CL-34	large_intestine	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons