DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PMSSS
Uniprot ID:
Q9H4Z2
Source protein:
Zinc finger protein 335
Source gene:
ZNF335
Class:
DEG_SPOP_SBC_1
Location:
180:184
E3 ligase:
SPOP
DEGRON score:
0.5585
ASA_SCORE:
86.56
COIL:
0.8792
CONS_SCORE:
0.6134
DSS_SCORE:
0.5438
HELIX:
0.0798
FCONS_SCORE:
1.0172
RIG_SCORE:
0.6443
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A192V
TCGA-AA-3984
COAD
TCGA
PMSSS
DEG_SPOP_SBC_1
0.1111
p.A192V
TCGA-BK-A6W3
UCEC
TCGA
PMSSS
DEG_SPOP_SBC_1
0.1111
p.D172G
TCGA-AX-A1C9
UCEC
TCGA
PMSSS
DEG_SPOP_SBC_1
0.1111
p.D172G
DO43098
UCEC
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1111
p.S189N
TCGA-FR-A7U9
SKCM
TCGA
PMSSS
DEG_SPOP_SBC_1
0.1944
p.E174K
DO44238
BRCA
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1667
p.E174D
DO23765
LUAD
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1667
p.R178W
DO45330
LUAD
ICGC
PMSSS
DEG_SPOP_SBC_1
0.2778
p.R178W
DO232761
PBCA
ICGC
PMSSS
DEG_SPOP_SBC_1
0.2778
p.G170S
DO230525
LUSC
ICGC
PMSSS
DEG_SPOP_SBC_1
0.0556
p.E172K
DO45526
LUSC
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1111
p.P192S
DO27421
LUSC
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1111
p.P192S
DO47833
STAD
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1111
p.R178Q
DO35442
PACA
ICGC
PMSSS
DEG_SPOP_SBC_1
0.2778
p.R181Q
DO232761
PBCA
ICGC
PMSSS
DEG_SPOP_SBC_1
0.7329
p.S188C
DO46877
RECA
ICGC
PMSSS
DEG_SPOP_SBC_1
0.2222
p.P187S
DO218900
SKCA
ICGC
PMSSS
DEG_SPOP_SBC_1
0.25
p.P175H
DO43258
UCEC
ICGC
PMSSS
DEG_SPOP_SBC_1
0.1944
p.S189C
SIDM00270
Head and Neck Carcinoma
GDSC
PMSSS
DEG_SPOP_SBC_1
0.1944
p.S189C
ACH-002294
Head and Neck Cancer
CCLE
PMSSS
DEG_SPOP_SBC_1
0.1944
p.S189C
PCI-15A
upper_aerodigestive_tract
COSMIC
PMSSS
DEG_SPOP_SBC_1
0.1944
p.I193T
SIDM01433
Kidney Carcinoma
GDSC
PMSSS
DEG_SPOP_SBC_1
0.0833
p.I193T
SIDM01729
Endometrial Carcinoma
GDSC
PMSSS
DEG_SPOP_SBC_1
0.0833
Drug responses associated with ZNF335 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PMSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15062
Zinc finger and BTB domain-containing protein 5
DEG_SPOP_SBC_1
170:174
PMSSS
SPOP
0.8158
More...
P01266
Thyroglobulin
DEG_SPOP_SBC_1
2443:2447
PMSSS
SPOP
0.5138
More...
P39880
Homeobox protein cut-like 1
DEG_SPOP_SBC_1
1060:1064
PMSSS
SPOP
0.9994
More...
Q2KHR2
DNA-binding protein RFX7
DEG_SPOP_SBC_1
285:289
PMSSS
SPOP
0.9583
More...
Q6AWC2
Protein WWC2
DEG_SPOP_SBC_1
569:573
PMSSS
SPOP
0.827
More...
Q6PCT2
F-box/LRR-repeat protein 19
DEG_SPOP_SBC_1
20:24
PMSSS
SPOP
0.8896
More...
Q96JG9
Zinc finger protein 469
DEG_SPOP_SBC_1
610:614
PMSSS
SPOP
0.8719
More...
Q9H0N0
Ras-related protein Rab-6C
DEG_SPOP_SBC_1
211:215
PMSSS
SPOP
0.9712
More...
Q9H4Z2
Zinc finger protein 335
DEG_SPOP_SBC_1
180:184
PMSSS
SPOP
0.5585
More...
Q9ULL8
Protein Shroom4
DEG_SPOP_SBC_1
813:817
PMSSS
SPOP
0.7425
More...
Q9ULT8
E3 ubiquitin-protein ligase HECTD1
DEG_SPOP_SBC_1
1527:1531
PMSSS
SPOP
0.9987
More...
Q9NW07
Zinc finger protein 358
DEG_SPOP_SBC_1
87:91
PMSSS
SPOP
0.9771
More...