DegronMD

Uniprot ID: Q9ULT8

Source protein: E3 ubiquitin-protein ligase HECTD1

Source gene: HECTD1

Class: DEG_SPOP_SBC_1

Location: 1527:1531

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 77.38

COIL: 0.753

CONS_SCORE: 0.4835

DSS_SCORE: 0.3892

HELIX: 0.159

FCONS_SCORE: 1.157

RIG_SCORE: 0.5975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1525V	TCGA-D3-A1Q3	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.G1525V	DO47509	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.S1529R	TCGA-IB-7651	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.7427
p.S1529R	DO46657	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7427
p.M1528V	TCGA-K4-A6MB	BLCA	TCGA	PMSSS	DEG_SPOP_SBC_1	0.6097
p.M1528V	DO44077	BLCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.6097
p.S1519N	DO225331	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1111
p.E1541D	DO222798	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0556
p.S1520F	DO228014	SKCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.5833
p.A1524S	SIDM01318	Hepatocellular Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.25
p.A1524S	ACH-001318	Liver Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons