DegronMD - Q9NW07(ZNF358)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L512P	TCGA-12-5299	GBM	TCGA	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.L512P	DO13330	GBM	ICGC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.L512P	ACH-001028	Rhabdoid	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.R460H	TCGA-28-5209	GBM	TCGA	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2778
p.R460H	DO11280	GBM	ICGC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2778
p.L452I	TCGA-4R-AA8I	LIHC	TCGA	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2778
p.L452I	DO49657	LIHC	ICGC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.2778
p.G481S	TCGA-58-8391	LUSC	TCGA	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation rewiring degron network	0.1944
p.G481S	DO45440	LUSC	ICGC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation rewiring degron network	0.1944
p.S493Y	TCGA-5L-AAT1	BRCA	TCGA	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation altering degron motif	0.712
p.S493Y	DO219594	BRCA	ICGC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation altering degron motif	0.712
p.S90L	TCGA-AJ-A3EL	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.7667
p.S90L	DO41542	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation altering degron motif	0.7667
p.P96S	TCGA-AP-A1DK	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.P96S	DO42033	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.1944
p.D93N	TCGA-CG-5719	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D93N	TCGA-EO-A22R	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D93N	TCGA-IB-7651	PAAD	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D93N	DO46657	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D93N	DO36881	READ	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D93N	DO38827	STAD	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D93N	DO42713	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2778
p.D505N	TCGA-CN-4723	HNSC	TCGA	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.2222
p.D505N	DO14830	HNSC	ICGC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.2222
p.P526S	TCGA-D1-A103	UCEC	TCGA	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.1111
p.P526S	DO42312	UCEC	ICGC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.1111
p.D95N	TCGA-EA-A3HU	CESC	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.D95N	TCGA-QF-A5YS	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.D95N	DO6320	CESC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.D95N	DO52426	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.2222
p.P510Q	TCGA-EE-A3AA	SKCM	TCGA	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.5924
p.P510Q	DO37571	SKCM	ICGC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.5924
p.P518Q	TCGA-EK-A2PM	CESC	TCGA	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7035
p.P518Q	DO49941	CESC	ICGC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7035
p.K477R	TCGA-EO-A22U	UCEC	TCGA	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation substituting flanking lysine	0.1944
p.K477R	DO43755	UCEC	ICGC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation substituting flanking lysine	0.1944
p.R483T	TCGA-GL-7773	KIRP	TCGA	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation rewiring degron network	0.25
p.R483T	DO20804	KIRP	ICGC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation rewiring degron network	0.25
p.P78S	DO222848	BTCA	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0833
p.G455V	DO229027	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.6421
p.G451V	DO229031	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.25
p.P101S	DO23214	LINC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0556
p.P101S	DO23506	LINC	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0556
p.P454L	DO231681	LINC	ICGC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.7582
p.S444C	DO26469	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0556
p.KA497KT	DO222837	MELA	ICGC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation substituting flanking lysine	0.1111
p.P508T	DO50657	ORCA	ICGC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.3056
p.A77P	DO51958	PRAD	ICGC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.0556
p.G455D	SIDM02059	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	454:458	Mutation altering degron motif	0.6087
p.P486T	SIDM02015	Colorectal Carcinoma	GDSC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation altering degron motif	0.7031
p.E492K	SIDM00662	Melanoma	GDSC	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation altering degron motif	0.591
p.E492K	ACH-000135	Non-Cancerous	CCLE	PSPTPVES	DEG_SCF_FBW7_1	486:493	Mutation altering degron motif	0.591
p.P518L	SIDM01139	Pancreatic Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.P518L	SIDM00697	Small Cell Lung Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.P518L	ACH-000042	Pancreatic Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.P518L	ACH-000830	Lung Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.P518L	NCI-H1436	lung	COSMIC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.P518L	PANC-02-03	pancreas	COSMIC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.6471
p.S517N	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7069
p.S517N	SIDM00282	Colorectal Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7069
p.S517N	ACH-000914	Lymphoma	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7069
p.S517N	ACH-000998	Colon/Colorectal Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7069
p.S517N	CW-2	large intestine	COSMIC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7069
p.S517N	HT	haematopoietic and lymphoid tissue	COSMIC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation altering degron motif	0.7069
p.D505Y	SIDM00157	Neuroblastoma	GDSC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.2222
p.D505Y	ACH-002261	Neuroblastoma	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.2222
p.D505Y	KP-N-YS	autonomic ganglia	COSMIC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.2222
p.D86N	SIDM00945	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.D86N	ACH-000895	Colon/Colorectal Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.D86N	CL-34	large intestine	COSMIC	PMSSS	DEG_SPOP_SBC_1	87:91	Mutation rewiring degron network	0.3056
p.P524R	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.1667
p.P524R	ACH-000378	Lung Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.1667
p.P524R	NCI-H647	lung	COSMIC	SPDLDPVPSP	DEG_COP1_1	509:518	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF358

UniProt ID: Q9NW07

Entrez ID: 140467

Protein name: Zinc finger protein 358

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF358 in