DegronMD

Uniprot ID: Q9NW07

Source protein: Zinc finger protein 358

Source gene: ZNF358

Class: DEG_COP1_1

Location: 509:518

E3 ligase: COP1

DEGRON score: 0.8788

ASA_SCORE: 65.3

COIL: 0.7788

CONS_SCORE: 0.5264

DSS_SCORE: 0.8771

HELIX: 0.0131

FCONS_SCORE: 0.7175

RIG_SCORE: 0.5314

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L512P	TCGA-12-5299	GBM	TCGA	SPDLDPVPSP	DEG_COP1_1	0.6471
p.L512P	DO13330	GBM	ICGC	SPDLDPVPSP	DEG_COP1_1	0.6471
p.L512P	ACH-001028	Rhabdoid	CCLE	SPDLDPVPSP	DEG_COP1_1	0.6471
p.D505N	TCGA-CN-4723	HNSC	TCGA	SPDLDPVPSP	DEG_COP1_1	0.2222
p.D505N	DO14830	HNSC	ICGC	SPDLDPVPSP	DEG_COP1_1	0.2222
p.P526S	TCGA-D1-A103	UCEC	TCGA	SPDLDPVPSP	DEG_COP1_1	0.1111
p.P526S	DO42312	UCEC	ICGC	SPDLDPVPSP	DEG_COP1_1	0.1111
p.P510Q	TCGA-EE-A3AA	SKCM	TCGA	SPDLDPVPSP	DEG_COP1_1	0.5924
p.P510Q	DO37571	SKCM	ICGC	SPDLDPVPSP	DEG_COP1_1	0.5924
p.P518Q	TCGA-EK-A2PM	CESC	TCGA	SPDLDPVPSP	DEG_COP1_1	0.7035
p.P518Q	DO49941	CESC	ICGC	SPDLDPVPSP	DEG_COP1_1	0.7035
p.P508T	DO50657	ORCA	ICGC	SPDLDPVPSP	DEG_COP1_1	0.3056
p.P518L	SIDM01139	Pancreatic Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	0.6471
p.P518L	SIDM00697	Small Cell Lung Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	0.6471
p.P518L	ACH-000042	Pancreatic Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	0.6471
p.P518L	ACH-000830	Lung Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	0.6471
p.P518L	NCI-H1436	lung	COSMIC	SPDLDPVPSP	DEG_COP1_1	0.6471
p.P518L	PANC-02-03	pancreas	COSMIC	SPDLDPVPSP	DEG_COP1_1	0.6471
p.S517N	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPDLDPVPSP	DEG_COP1_1	0.7069
p.S517N	SIDM00282	Colorectal Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	0.7069
p.S517N	ACH-000914	Lymphoma	CCLE	SPDLDPVPSP	DEG_COP1_1	0.7069
p.S517N	ACH-000998	Colon/Colorectal Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	0.7069
p.S517N	CW-2	large_intestine	COSMIC	SPDLDPVPSP	DEG_COP1_1	0.7069
p.S517N	HT	haematopoietic_and_lymphoid_tissue	COSMIC	SPDLDPVPSP	DEG_COP1_1	0.7069
p.D505Y	SIDM00157	Neuroblastoma	GDSC	SPDLDPVPSP	DEG_COP1_1	0.2222
p.D505Y	ACH-002261	Neuroblastoma	CCLE	SPDLDPVPSP	DEG_COP1_1	0.2222
p.D505Y	KP-N-YS	autonomic_ganglia	COSMIC	SPDLDPVPSP	DEG_COP1_1	0.2222
p.P524R	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	SPDLDPVPSP	DEG_COP1_1	0.1667
p.P524R	ACH-000378	Lung Cancer	CCLE	SPDLDPVPSP	DEG_COP1_1	0.1667
p.P524R	NCI-H647	lung	COSMIC	SPDLDPVPSP	DEG_COP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPDLDPVPSP

Degron related mutations and impact score

Drug responses associated with ZNF358 mutations

All proteins holding degron of SPDLDPVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW07	Zinc finger protein 358	DEG_COP1_1	509:518	SPDLDPVPSP	COP1	0.8788	More...