DegronMD

Uniprot ID: Q9NW07

Source protein: Zinc finger protein 358

Source gene: ZNF358

Class: DEG_SCF_FBW7_1

Location: 486:493

E3 ligase: FBXW7

DEGRON score: 0.9542

ASA_SCORE: 65.8875

COIL: 0.7536

CONS_SCORE: 0.6578

DSS_SCORE: 0.8584

HELIX: 0.012

FCONS_SCORE: 0.9622

RIG_SCORE: 0.4988

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S493Y	TCGA-5L-AAT1	BRCA	TCGA	PSPTPVES	DEG_SCF_FBW7_1	0.712
p.S493Y	DO219594	BRCA	ICGC	PSPTPVES	DEG_SCF_FBW7_1	0.712
p.P486T	SIDM02015	Colorectal Carcinoma	GDSC	PSPTPVES	DEG_SCF_FBW7_1	0.7031
p.E492K	SIDM00662	Melanoma	GDSC	PSPTPVES	DEG_SCF_FBW7_1	0.591
p.E492K	ACH-000135	Non-Cancerous	CCLE	PSPTPVES	DEG_SCF_FBW7_1	0.591
p.R483T	TCGA-GL-7773	KIRP	TCGA	PSPTPVES	DEG_SCF_FBW7_1	0.25
p.R483T	DO20804	KIRP	ICGC	PSPTPVES	DEG_SCF_FBW7_1	0.25
p.G481S	TCGA-58-8391	LUSC	TCGA	PSPTPVES	DEG_SCF_FBW7_1	0.1944
p.G481S	DO45440	LUSC	ICGC	PSPTPVES	DEG_SCF_FBW7_1	0.1944
p.K477R	TCGA-EO-A22U	UCEC	TCGA	PSPTPVES	DEG_SCF_FBW7_1	0.1944
p.K477R	DO43755	UCEC	ICGC	PSPTPVES	DEG_SCF_FBW7_1	0.1944
p.KA497KT	DO222837	MELA	ICGC	PSPTPVES	DEG_SCF_FBW7_1	0.1111

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW07	Zinc finger protein 358	DEG_SCF_FBW7_1	486:493	PSPTPVES	FBXW7	0.9542	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons