DegronMD

Uniprot ID: Q6AWC2

Source protein: Protein WWC2

Source gene: WWC2

Class: DEG_APCC_DBOX_1

Location: 457:465

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.947

ASA_SCORE: 71.0889

COIL: 0.6878

CONS_SCORE: 0.6618

DSS_SCORE: 0.3761

HELIX: 0.2101

FCONS_SCORE: 1.6667

RIG_SCORE: 0.6413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S457T	TCGA-37-3783	LUSC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.6005
p.S448L	TCGA-56-8629	LUSC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.0833
p.E468K	TCGA-AR-A1AJ	BRCA	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.25
p.S473N	TCGA-B5-A1MR	UCEC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.1111
p.R458I	TCGA-DF-A2KU	UCEC	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.8102
p.S463F	TCGA-EE-A2GD	SKCM	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.6871
p.Y470H	TCGA-G9-6363	PRAD	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.6389
p.N462S	TCGA-HU-A4G2	STAD	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.5958
p.S475R	TCGA-HU-A4GT	STAD	TCGA	SRGSLNSLS	DEG_APCC_DBOX_1	0.0556
p.A455S	DO228483	BRCA	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	0.2778
p.A455S	DO229010	COCA	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	0.2778
p.A455S	DO234285	ESAD	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	0.2778
p.A455S	DO229489	LAML	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	0.2778
p.R467G	DO228936	LICA	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	0.2778
p.D469G	DO26963	LUSC	ICGC	SRGSLNSLS	DEG_APCC_DBOX_1	0.2222
p.A447V	SIDM00447	B-Lymphoblastic Leukemia	GDSC	SRGSLNSLS	DEG_APCC_DBOX_1	0.0556
p.A447V	ACH-000960	Leukemia	CCLE	SRGSLNSLS	DEG_APCC_DBOX_1	0.0556
p.A447V	REH	haematopoietic_and_lymphoid_tissue	COSMIC	SRGSLNSLS	DEG_APCC_DBOX_1	0.0556
p.R450Q	SIDM01665	Colorectal Carcinoma	GDSC	SRGSLNSLS	DEG_APCC_DBOX_1	0.1389
p.R450W	SIDM01387	Small Cell Lung Carcinoma	GDSC	SRGSLNSLS	DEG_APCC_DBOX_1	0.1389
p.S475N	ACH-001970	Metastasis	CCLE	SRGSLNSLS	DEG_APCC_DBOX_1	0.0556
p.V454I	K5	thyroid	COSMIC	SRGSLNSLS	DEG_APCC_DBOX_1	0.25
p.L447S	CAL-148	breast	COSMIC	SRGSLNSLS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AWC2	Protein WWC2	DEG_APCC_DBOX_1	457:465	SRGSLNSLS	APC,CDC20,FZR1	0.947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons