DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: DEG_SPOP_SBC_1

Location: 2782:2786

E3 ligase: SPOP

DEGRON score: 0.6031

ASA_SCORE: 88.36

COIL: 0.9438

CONS_SCORE: 0.4263

DSS_SCORE: 0.7418

HELIX: 0.036

FCONS_SCORE: 0.8993

RIG_SCORE: 0.6001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2781L	TCGA-AX-A2HC	UCEC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.3056
p.P2794S	TCGA-D1-A17H	UCEC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.1111
p.T2794M	DO225167	BRCA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.E2792D	DO8898	COAD	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1667
p.S2772N	DO50446	ESAD	ICGC	ADSTT	DEG_SPOP_SBC_1	0.0556
p.G2788D	DO11854	GBM	ICGC	ADSTT	DEG_SPOP_SBC_1	0.2778
p.W2790L	DO228974	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.2222
p.E2791D	DO228976	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75367	Core histone macro-H2A.1	DEG_SPOP_SBC_1	171:175	ADSTT	SPOP	0.946	More...
O75367	Core histone macro-H2A.1	DEG_SPOP_SBC_1	171:175	ADSTT	SPOP	0.946	More...
Q3MIW9	Mucin-like protein 3	DEG_SPOP_SBC_1	143:147	ADSTT	SPOP	0.8151	More...
Q86VF2	Immunoglobulin-like and fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	699:703	ADSTT	SPOP	0.9912	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2782:2786	ADSTT	SPOP	0.6031	More...
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_SPOP_SBC_1	941:945	ADSTT	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons