DegronMD

Uniprot ID: Q9BXX2

Source protein: Ankyrin repeat domain-containing protein 30B

Source gene: ANKRD30B

Class: DEG_SPOP_SBC_1

Location: 941:945

E3 ligase: SPOP

DEGRON score: 0.998

ASA_SCORE: 75.48

COIL: 0.7668

CONS_SCORE: 0.3718

DSS_SCORE: 0.4156

HELIX: 0.1702

FCONS_SCORE: 1.4604

RIG_SCORE: 0.7593

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W933L	TCGA-18-3411	LUSC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.1111
p.W933L	TCGA-46-3768	LUSC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.1111
p.W933L	DO26466	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.W933L	DO26758	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.N935Y	TCGA-5M-AAT6	COAD	TCGA	ADSTT	DEG_SPOP_SBC_1	0.1667
p.N935Y	DO223703	COAD	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1667
p.L931S	TCGA-63-7023	LUSC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.0556
p.L931S	DO26494	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.0556
p.A952T	TCGA-A5-A0G2	UCEC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.1389
p.A952T	DO41235	UCEC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1389
p.L953V	TCGA-C5-A8ZZ	CESC	TCGA	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953V	DO49912	CESC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.S943A	DO234437	ESAD	ICGC	ADSTT	DEG_SPOP_SBC_1	0.7588
p.A952S	DO229027	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1389
p.A952E	DO229026	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.1389
p.T945S	DO229058	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.6005
p.A941V	DO229062	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.5825
p.D942Y	DO231070	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.6214
p.K936N	SIDM01104	Melanoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.3056
p.K936N	ACH-000640	Skin Cancer	CCLE	ADSTT	DEG_SPOP_SBC_1	0.3056
p.K936N	SK-MEL-31	skin	COSMIC	ADSTT	DEG_SPOP_SBC_1	0.3056
p.L953P	SIDM00845	Burkitt's Lymphoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM01112	Osteosarcoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM00878	Breast Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM00879	Breast Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM00493	Other Solid Cancers	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM00721	Small Cell Lung Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM01140	Ovarian Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.L953P	SIDM00628	Breast Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.R940T	SIDM01175	Other Sarcomas	GDSC	ADSTT	DEG_SPOP_SBC_1	0.3056
p.R940T	ACH-002309	Sarcoma	CCLE	ADSTT	DEG_SPOP_SBC_1	0.3056
p.R940T	SW684	soft_tissue	COSMIC	ADSTT	DEG_SPOP_SBC_1	0.3056
p.L953I	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	0.1111
p.D951H	ACH-001395	Breast Cancer	CCLE	ADSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75367	Core histone macro-H2A.1	DEG_SPOP_SBC_1	171:175	ADSTT	SPOP	0.946	More...
O75367	Core histone macro-H2A.1	DEG_SPOP_SBC_1	171:175	ADSTT	SPOP	0.946	More...
Q3MIW9	Mucin-like protein 3	DEG_SPOP_SBC_1	143:147	ADSTT	SPOP	0.8151	More...
Q86VF2	Immunoglobulin-like and fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	699:703	ADSTT	SPOP	0.9912	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2782:2786	ADSTT	SPOP	0.6031	More...
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_SPOP_SBC_1	941:945	ADSTT	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSTT

Degron related mutations and impact score

Drug responses associated with ANKRD30B mutations

All proteins holding degron of ADSTT