DegronMD - Q86VF2(IGFN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G696D	DO229010	COCA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.25
p.G696D	DO229016	COCA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.25
p.G696D	DO229005	COCA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.25
p.G696D	DO230993	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.25
p.G696D	DO218838	SKCA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.25
p.Q418R	DO229010	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.Q418R	DO229010	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.Q418R	DO229013	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.Q418R	DO229013	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.Q418R	DO229016	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.Q418R	DO229016	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.Q418R	DO229003	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.Q418R	DO229003	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.Q418R	DO229005	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.Q418R	DO229005	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.Q418R	DO51031	LAML	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.Q418R	DO51031	LAML	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.2222
p.D702Y	DO229025	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation altering degron motif	0.7325
p.S435F	DO222749	MELA	ICGC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1389
p.S435F	DO222749	MELA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1389
p.S435F	ACH-000552	Colon/Colorectal Cancer	CCLE	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1389
p.S435F	ACH-000552	Colon/Colorectal Cancer	CCLE	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1389
p.W695R	DO233292	NACA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.E707K	DO229456	SKCA	ICGC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.F704L	OVCAR-4	ovary	COSMIC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.3056
p.T437K	SW900	lung	COSMIC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.0833
p.T437K	SW900	lung	COSMIC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.0833
p.E710K	COLO-792	skin	COSMIC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.1389
p.G695S	NCI-H2141	lung	COSMIC	ADSTT	DEG_SPOP_SBC_1	699:703	Mutation rewiring degron network	0.2222
p.R415M	NCI-H292	lung	COSMIC	LDIYGE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1111
p.R415M	NCI-H292	lung	COSMIC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	422:428	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGFN1

UniProt ID: Q86VF2

Entrez ID: 91156

Protein name: Immunoglobulin-like and fibronectin type III domain-containing protein 1 (EEF1A2-binding protein 1) (KY-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGFN1 in