DegronMD

Uniprot ID: Q86VF2

Source protein: Immunoglobulin-like and fibronectin type III domain-containing protein 1

Source gene: IGFN1

Class: LIG_APCC_ABBAyCdc20_2

Location: 422:428

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9692

ASA_SCORE: 82.3857

COIL: 0.4346

CONS_SCORE: 0.3883

DSS_SCORE: 0.6255

HELIX: 0.0197

FCONS_SCORE: 1.1502

RIG_SCORE: 0.7211

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q418R	DO229010	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q418R	DO229013	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q418R	DO229016	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q418R	DO229003	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q418R	DO229005	COCA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q418R	DO51031	LAML	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S435F	DO222749	MELA	ICGC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S435F	ACH-000552	Colon/Colorectal Cancer	CCLE	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R415M	NCI-H292	lung	COSMIC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T437K	SW900	lung	COSMIC	RLDIYGE	LIG_APCC_ABBAyCdc20_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VF2	Immunoglobulin-like and fibronectin type III domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	422:428	RLDIYGE	APC,CDC20,FZR1	0.9692	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons