DegronMD

Uniprot ID: Q86VF2

Source protein: Immunoglobulin-like and fibronectin type III domain-containing protein 1

Source gene: IGFN1

Class: DEG_SPOP_SBC_1

Location: 699:703

E3 ligase: SPOP

DEGRON score: 0.9912

ASA_SCORE: 57.24

COIL: 0.6976

CONS_SCORE: 0.3834

DSS_SCORE: 0.4469

HELIX: 0.0278

FCONS_SCORE: 0.7876

RIG_SCORE: 0.7279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G696D	DO229010	COCA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.25
p.G696D	DO229016	COCA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.25
p.G696D	DO229005	COCA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.25
p.G696D	DO230993	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	0.25
p.G696D	DO218838	SKCA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.25
p.D702Y	DO229025	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.7325
p.W695R	DO233292	NACA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.2222
p.E707K	DO229456	SKCA	ICGC	ADSTT	DEG_SPOP_SBC_1	0.2222
p.F704L	OVCAR-4	ovary	COSMIC	ADSTT	DEG_SPOP_SBC_1	0.3056
p.E710K	COLO-792	skin	COSMIC	ADSTT	DEG_SPOP_SBC_1	0.1389
p.G695S	NCI-H2141	lung	COSMIC	ADSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75367	Core histone macro-H2A.1	DEG_SPOP_SBC_1	171:175	ADSTT	SPOP	0.946	More...
O75367	Core histone macro-H2A.1	DEG_SPOP_SBC_1	171:175	ADSTT	SPOP	0.946	More...
Q3MIW9	Mucin-like protein 3	DEG_SPOP_SBC_1	143:147	ADSTT	SPOP	0.8151	More...
Q86VF2	Immunoglobulin-like and fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	699:703	ADSTT	SPOP	0.9912	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2782:2786	ADSTT	SPOP	0.6031	More...
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_SPOP_SBC_1	941:945	ADSTT	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons