DegronMD - Q9BXX2(ANKRD30B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1103Y	TCGA-06-0192	GBM	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.H1103Y	DO13420	GBM	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.W933L	TCGA-18-3411	LUSC	TCGA	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.W933L	TCGA-46-3768	LUSC	TCGA	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.W933L	DO26466	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.W933L	DO26758	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.C374W	TCGA-27-1832	GBM	TCGA	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2222
p.C374W	DO10912	GBM	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2222
p.K1117M	TCGA-38-4626	LUAD	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation substituting flanking lysine	0.2778
p.K1117M	DO24447	LUAD	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation substituting flanking lysine	0.2778
p.Y1112S	TCGA-44-7660	LUAD	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation blocking phosphorylation signal	0.75
p.Y1112S	DO23834	LUAD	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation blocking phosphorylation signal	0.75
p.N935Y	TCGA-5M-AAT6	COAD	TCGA	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1667
p.N935Y	DO223703	COAD	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1667
p.L931S	TCGA-63-7023	LUSC	TCGA	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.0556
p.L931S	DO26494	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.0556
p.G222S	TCGA-A5-A0G2	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.1389
p.G222S	DO41235	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.1389
p.V231I	TCGA-A5-A0G2	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.5965
p.V231I	TCGA-DF-A2KU	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.5965
p.V231I	DO223286	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.5965
p.V231I	DO41235	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.5965
p.V231I	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.5965
p.V231I	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.5965
p.A952T	TCGA-A5-A0G2	UCEC	TCGA	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1389
p.A952T	DO41235	UCEC	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1389
p.G238V	TCGA-AJ-A3EL	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.2222
p.G238V	DO229008	LICA	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.2222
p.G238V	DO41542	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.2222
p.V385F	TCGA-AP-A0LM	UCEC	TCGA	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2778
p.V385F	DO43306	UCEC	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2778
p.A241T	TCGA-AP-A1DK	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.1389
p.A241T	DO42033	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.1389
p.L953V	TCGA-C5-A8ZZ	CESC	TCGA	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953V	DO49912	CESC	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.I1118F	TCGA-D1-A17Q	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.1389
p.I1118F	DO41903	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.1389
p.E387G	TCGA-D1-A17U	UCEC	TCGA	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2222
p.E387G	DO41887	UCEC	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2222
p.K1108N	TCGA-EB-A24D	SKCM	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation altering degron motif	0.6918
p.K1108N	DO37440	SKCM	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation altering degron motif	0.6918
p.H1105P	TCGA-EE-A181	SKCM	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2778
p.H1105P	DO37444	SKCM	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2778
p.E384K	TCGA-EE-A29E	SKCM	TCGA	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.3056
p.E384K	DO37831	SKCM	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.3056
p.A376T	TCGA-F7-A624	HNSC	TCGA	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2778
p.A376T	DO44440	HNSC	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.2778
p.V1098I	TCGA-FS-A1ZF	SKCM	TCGA	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.0833
p.V1098I	DO38039	SKCM	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.0833
p.G377V	TCGA-ZJ-AAXU	CESC	TCGA	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.3056
p.G377V	DO219759	CESC	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.3056
p.E384D	DO50384	ESAD	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.3056
p.D235G	DO234157	ESAD	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.3056
p.S943A	DO234437	ESAD	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.7588
p.K1117T	DO233732	GACA	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation substituting flanking lysine	0.2778
p.A952S	DO229027	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1389
p.A952E	DO229026	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1389
p.V375L	DO229045	LICA	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.T945S	DO229058	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.6005
p.P380S	DO229057	LICA	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation altering degron motif	0.6752
p.A941V	DO229062	LICA	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.5825
p.V378L	DO23312	LINC	ICGC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation altering degron motif	0.5654
p.D942Y	DO231070	LUSC	ICGC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.6214
p.L225P	DO231078	LUSC	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.2222
p.E219D	DO228263	MALY	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.0556
p.E1109K	DO220886	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation altering degron motif	0.7022
p.E1109K	DO220903	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation altering degron motif	0.7022
p.E1109K	DO222420	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation altering degron motif	0.7022
p.A233T	DO229253	THCA	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation altering degron motif	0.6028
p.H237R	DO229268	THCA	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.25
p.R243S	DO229208	THCA	ICGC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.0833
p.K936N	SIDM01104	Melanoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation substituting flanking lysine	0.3056
p.K936N	ACH-000640	Skin Cancer	CCLE	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation substituting flanking lysine	0.3056
p.K936N	SK-MEL-31	skin	COSMIC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation substituting flanking lysine	0.3056
p.V375M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00845	Burkitt's Lymphoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00846	Cervical Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM01112	Osteosarcoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00878	Breast Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00907	Burkitt's Lymphoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00721	Small Cell Lung Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM01140	Ovarian Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.V375M	SIDM00628	Breast Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.25
p.T390I	SIDM00234	Other Solid Cancers	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.1389
p.T390I	ACH-002201	Cervical Cancer	CCLE	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.1389
p.T390I	TC-YIK	cervix	COSMIC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.1389
p.L953P	SIDM00845	Burkitt's Lymphoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM01112	Osteosarcoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM00878	Breast Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM00879	Breast Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM00493	Other Solid Cancers	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM00721	Small Cell Lung Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM01140	Ovarian Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.L953P	SIDM00628	Breast Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.R940T	SIDM01175	Other Sarcomas	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.3056
p.R940T	ACH-002309	Sarcoma	CCLE	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.3056
p.R940T	SW684	soft tissue	COSMIC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.3056
p.T390A	SIDM00266	Ewing's Sarcoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.1389
p.T390A	ACH-002103	Bone Cancer	CCLE	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.1389
p.T390A	ES1	bone	COSMIC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.1389
p.L1101V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.1667
p.L1101V	ACH-000605	Esophageal Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.1667
p.L1101V	TE-6	oesophagus	COSMIC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.1667
p.D1115Y	SIDM00264	Ewing's Sarcoma	GDSC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.D1115Y	ACH-002105	Bone Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.D1115Y	ES4	bone	COSMIC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.S369F	SIDM00417	Plasma Cell Myeloma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.0833
p.S369F	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.0833
p.S369F	ACH-000626	Myeloma	CCLE	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.0833
p.S369F	U-266	haematopoietic and lymphoid tissue	COSMIC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation rewiring degron network	0.0833
p.H1103P	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.H1103P	ACH-000482	Lung Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.H1103P	RERF-LC-KJ	lung	COSMIC	VKENK	DEG_APCC_KENBOX_2	1107:1111	Mutation rewiring degron network	0.2222
p.V221D	SIDM01522	B-Lymphoblastic Leukemia	GDSC	VDVFAE	LIG_APCC_ABBA_1	229:234	Mutation rewiring degron network	0.1111
p.T379I	SIDM01560	Rhabdomyosarcoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	378:383	Mutation altering degron motif	0.7078
p.L953I	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1111
p.D951H	ACH-001395	Breast Cancer	CCLE	ADSTT	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD30B

UniProt ID: Q9BXX2

Entrez ID:

Protein name: Ankyrin repeat domain-containing protein 30B (Serologically defined breast cancer antigen NY-BR-1.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD30B in