DegronMD

Uniprot ID: Q9BXX2

Source protein: Ankyrin repeat domain-containing protein 30B

Source gene: ANKRD30B

Class: DEG_APCC_KENBOX_2

Location: 1107:1111

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9176

ASA_SCORE: 105.56

COIL: 0.1996

CONS_SCORE: 0.366

DSS_SCORE: 0.173

HELIX: 0.8014

FCONS_SCORE: 1.2146

RIG_SCORE: 0.7906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1103Y	TCGA-06-0192	GBM	TCGA	VKENK	DEG_APCC_KENBOX_2	0.2222
p.H1103Y	DO13420	GBM	ICGC	VKENK	DEG_APCC_KENBOX_2	0.2222
p.K1117M	TCGA-38-4626	LUAD	TCGA	VKENK	DEG_APCC_KENBOX_2	0.2778
p.K1117M	DO24447	LUAD	ICGC	VKENK	DEG_APCC_KENBOX_2	0.2778
p.Y1112S	TCGA-44-7660	LUAD	TCGA	VKENK	DEG_APCC_KENBOX_2	0.75
p.Y1112S	DO23834	LUAD	ICGC	VKENK	DEG_APCC_KENBOX_2	0.75
p.I1118F	TCGA-D1-A17Q	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	0.1389
p.I1118F	DO41903	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	0.1389
p.K1108N	TCGA-EB-A24D	SKCM	TCGA	VKENK	DEG_APCC_KENBOX_2	0.6918
p.K1108N	DO37440	SKCM	ICGC	VKENK	DEG_APCC_KENBOX_2	0.6918
p.H1105P	TCGA-EE-A181	SKCM	TCGA	VKENK	DEG_APCC_KENBOX_2	0.2778
p.H1105P	DO37444	SKCM	ICGC	VKENK	DEG_APCC_KENBOX_2	0.2778
p.V1098I	TCGA-FS-A1ZF	SKCM	TCGA	VKENK	DEG_APCC_KENBOX_2	0.0833
p.V1098I	DO38039	SKCM	ICGC	VKENK	DEG_APCC_KENBOX_2	0.0833
p.K1117T	DO233732	GACA	ICGC	VKENK	DEG_APCC_KENBOX_2	0.2778
p.E1109K	DO220886	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	0.7022
p.E1109K	DO220903	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	0.7022
p.E1109K	DO222420	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	0.7022
p.L1101V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	VKENK	DEG_APCC_KENBOX_2	0.1667
p.L1101V	ACH-000605	Esophageal Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	0.1667
p.L1101V	TE-6	oesophagus	COSMIC	VKENK	DEG_APCC_KENBOX_2	0.1667
p.D1115Y	SIDM00264	Ewing's Sarcoma	GDSC	VKENK	DEG_APCC_KENBOX_2	0.2222
p.D1115Y	ACH-002105	Bone Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	0.2222
p.D1115Y	ES4	bone	COSMIC	VKENK	DEG_APCC_KENBOX_2	0.2222
p.H1103P	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VKENK	DEG_APCC_KENBOX_2	0.2222
p.H1103P	ACH-000482	Lung Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	0.2222
p.H1103P	RERF-LC-KJ	lung	COSMIC	VKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14966	Ras-related protein Rab-7L1	DEG_APCC_KENBOX_2	156:160	VKENK	APC,CDC20,FZR1	0.8907	More...
O75420	GRB10-interacting GYF protein 1	DEG_APCC_KENBOX_2	51:55	VKENK	APC,CDC20,FZR1	0.9245	More...
P63128	Endogenous retrovirus group K member 9 Pol protein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.525	More...
P62684	Endogenous retrovirus group K member 113 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9925	More...
P63126	Endogenous retrovirus group K member 9 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.854	More...
P63130	Endogenous retrovirus group K member 7 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9428	More...
P63145	Endogenous retrovirus group K member 24 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8705	More...
P87889	Endogenous retrovirus group K member 10 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9753	More...
Q7LDI9	Endogenous retrovirus group K member 6 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8189	More...
Q9HDB9	Endogenous retrovirus group K member 5 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9912	More...
Q9YNA8	Endogenous retrovirus group K member 19 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9866	More...
P62683	Endogenous retrovirus group K member 21 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8826	More...
P62685	Endogenous retrovirus group K member 8 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9243	More...
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_APCC_KENBOX_2	1107:1111	VKENK	APC,CDC20,FZR1	0.9176	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKENK

Degron related mutations and impact score

Drug responses associated with ANKRD30B mutations

All proteins holding degron of VKENK