DegronMD

Uniprot ID: O14966

Source protein: Ras-related protein Rab-7L1

Source gene: RAB29

Class: DEG_APCC_KENBOX_2

Location: 156:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8907

ASA_SCORE: 71.12

COIL: 0.8368

CONS_SCORE: 0.7006

DSS_SCORE: 0.3776

HELIX: 0.1188

FCONS_SCORE: 1.0499

RIG_SCORE: 0.7901

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T152P	SIDM01161	Other Sarcomas	GDSC	VKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14966	Ras-related protein Rab-7L1	DEG_APCC_KENBOX_2	156:160	VKENK	APC,CDC20,FZR1	0.8907	More...
O75420	GRB10-interacting GYF protein 1	DEG_APCC_KENBOX_2	51:55	VKENK	APC,CDC20,FZR1	0.9245	More...
P63128	Endogenous retrovirus group K member 9 Pol protein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.525	More...
P62684	Endogenous retrovirus group K member 113 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9925	More...
P63126	Endogenous retrovirus group K member 9 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.854	More...
P63130	Endogenous retrovirus group K member 7 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9428	More...
P63145	Endogenous retrovirus group K member 24 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8705	More...
P87889	Endogenous retrovirus group K member 10 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9753	More...
Q7LDI9	Endogenous retrovirus group K member 6 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8189	More...
Q9HDB9	Endogenous retrovirus group K member 5 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9912	More...
Q9YNA8	Endogenous retrovirus group K member 19 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9866	More...
P62683	Endogenous retrovirus group K member 21 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8826	More...
P62685	Endogenous retrovirus group K member 8 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9243	More...
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_APCC_KENBOX_2	1107:1111	VKENK	APC,CDC20,FZR1	0.9176	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKENK

Degron related mutations and impact score

Drug responses associated with RAB29 mutations

All proteins holding degron of VKENK