RAB29
UniProt ID: O14966
Entrez ID: 8934
Protein name: Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as ...
FUNCTION: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815}.
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GO - Biological processes (BP):
cell differentiation [GO:0030154]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular pro...
cell differentiation [GO:0030154]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; mitochondrion organization [GO:0007005]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of receptor recycling [GO:0001921]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization to ciliary membrane [GO:1903441]; protein localization to membrane [GO:0072657]; regulation of neuron death [GO:1901214]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synapse assembly [GO:0007416]; T cell activation [GO:0042110]; toxin transport [GO:1901998]; viral RNA genome replication [GO:0039694]
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GO - Molecular function (MF):
dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]...
dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellul...
cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]
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RAB29
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Kaplan plot for RAB29 in
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*NOTE: the Kaplan plots were collected from OncoLnc