DegronMD - O75420(GIGYF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E59Q	TCGA-2Y-A9GW	LIHC	TCGA	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.2222
p.E59Q	DO219511	LIHC	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.2222
p.E53D	TCGA-AA-3855	COAD	TCGA	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation altering degron motif	0.6758
p.E53D	DO10742	COAD	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation altering degron motif	0.6758
p.N54S	TCGA-AP-A0LM	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation altering degron motif	0.7069
p.N54S	DO43306	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation altering degron motif	0.7069
p.K35T	TCGA-CV-5434	HNSC	TCGA	DYR	CBL_MET	38:40	Mutation blocking ubiquitination signal	0.6944
p.K35T	DO14358	HNSC	ICGC	DYR	CBL_MET	38:40	Mutation blocking ubiquitination signal	0.6944
p.E64K	TCGA-D1-A101	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.0833
p.E64K	DO43955	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.0833
p.G999V	TCGA-EE-A3AG	SKCM	TCGA	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.0556
p.G999V	DO37471	SKCM	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.0556
p.R40C	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	38:40	Mutation altering degron motif	0.8301
p.R40C	DO43755	UCEC	ICGC	DYR	CBL_MET	38:40	Mutation altering degron motif	0.8301
p.K1005N	TCGA-EY-A215	UCEC	TCGA	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation substituting flanking lysine	0.3333
p.K1005N	DO42665	UCEC	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation substituting flanking lysine	0.3333
p.V51I	TCGA-FI-A2EX	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation altering degron motif	0.5965
p.V51I	DO42352	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation altering degron motif	0.5965
p.G999R	TCGA-WS-AB45	COAD	TCGA	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.0556
p.G999R	DO51734	COAD	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.0556
p.G999R	DO229248	THCA	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.0556
p.P794T	DO228948	LICA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.1111
p.H1012N	DO228952	LICA	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation altering degron motif	0.7423
p.P1015T	DO228974	LICA	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.3056
p.P1015T	DO229026	LICA	ICGC	LMLHSD	LIG_APCC_ABBA_1	1009:1014	Mutation rewiring degron network	0.3056
p.LY49LH	DO220903	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0
p.LY49LH	DO220903	MELA	ICGC	DYR	CBL_MET	38:40	Mutation rewiring degron network	0
p.Y50H	DO220903	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.3056
p.Y50H	DO220903	MELA	ICGC	DYR	CBL_MET	38:40	Mutation rewiring degron network	0.0556
p.L49V	DO46420	OV	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.2778
p.L49V	DO46420	OV	ICGC	DYR	CBL_MET	38:40	Mutation rewiring degron network	0.0833
p.E44K	DO33224	PACA	ICGC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.1389
p.E44K	DO33224	PACA	ICGC	DYR	CBL_MET	38:40	Mutation rewiring degron network	0.2222
p.P800L	DO232224	PBCA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.2778
p.R792L	DO229259	THCA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.0556
p.V818A	DO229211	THCA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.1111
p.M46I	SIDM01280	Esophageal Carcinoma	GDSC	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.1944
p.M46I	SIDM01280	Esophageal Carcinoma	GDSC	DYR	CBL_MET	38:40	Mutation rewiring degron network	0.1667
p.N801Y	SIDM00689	B-Lymphoblastic Leukemia	GDSC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.3056
p.N801Y	ACH-000151	Leukemia	CCLE	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.3056
p.Y39C	SIDM00367	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	38:40	Mutation altering degron motif	0.7087
p.Y39C	ACH-002197	Lung Cancer	CCLE	DYR	CBL_MET	38:40	Mutation altering degron motif	0.7087
p.Y39C	SBC-3	lung	COSMIC	DYR	CBL_MET	38:40	Mutation altering degron motif	0.7087
p.N801S	SIDM00259	Neuroblastoma	GDSC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.3056
p.T811S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.3056
p.T811S	ACH-000797	Non-Cancerous	CCLE	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.3056
p.E59K	ACH-000279	Bone Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	51:55	Mutation rewiring degron network	0.2222
p.A795S	ACH-000809	Esophageal Cancer	CCLE	HRVQLGGLG	DEG_APCC_DBOX_1	802:810	Mutation rewiring degron network	0.1389
p.M31V	ACH-002659	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	38:40	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GIGYF1

UniProt ID: O75420

Entrez ID:

Protein name: GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GIGYF1 in