DegronMD

Uniprot ID: O75420

Source protein: GRB10-interacting GYF protein 1

Source gene: GIGYF1

Class: LIG_APCC_ABBA_1

Location: 1009:1014

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5973

ASA_SCORE: 83.5667

COIL: 0.7152

CONS_SCORE: 0.3776

DSS_SCORE: 0.404

HELIX: 0.0727

FCONS_SCORE: 0.9889

RIG_SCORE: 0.7332

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G999V	TCGA-EE-A3AG	SKCM	TCGA	LMLHSD	LIG_APCC_ABBA_1	0.0556
p.G999V	DO37471	SKCM	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.0556
p.K1005N	TCGA-EY-A215	UCEC	TCGA	LMLHSD	LIG_APCC_ABBA_1	0.3333
p.K1005N	DO42665	UCEC	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.3333
p.G999R	TCGA-WS-AB45	COAD	TCGA	LMLHSD	LIG_APCC_ABBA_1	0.0556
p.G999R	DO51734	COAD	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.0556
p.G999R	DO229248	THCA	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.0556
p.H1012N	DO228952	LICA	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.7423
p.P1015T	DO228974	LICA	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.3056
p.P1015T	DO229026	LICA	ICGC	LMLHSD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75420	GRB10-interacting GYF protein 1	LIG_APCC_ABBA_1	1009:1014	LMLHSD	APC,CDC20,FZR1	0.5973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons