DegronMD

Uniprot ID: O75420

Source protein: GRB10-interacting GYF protein 1

Source gene: GIGYF1

Class: DEG_APCC_DBOX_1

Location: 802:810

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8558

ASA_SCORE: 82.7

COIL: 0.7428

CONS_SCORE: 0.3491

DSS_SCORE: 0.6188

HELIX: 0.184

FCONS_SCORE: 0.9931

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P794T	DO228948	LICA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	0.1111
p.P800L	DO232224	PBCA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	0.2778
p.R792L	DO229259	THCA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	0.0556
p.V818A	DO229211	THCA	ICGC	HRVQLGGLG	DEG_APCC_DBOX_1	0.1111
p.N801Y	SIDM00689	B-Lymphoblastic Leukemia	GDSC	HRVQLGGLG	DEG_APCC_DBOX_1	0.3056
p.N801Y	ACH-000151	Leukemia	CCLE	HRVQLGGLG	DEG_APCC_DBOX_1	0.3056
p.N801S	SIDM00259	Neuroblastoma	GDSC	HRVQLGGLG	DEG_APCC_DBOX_1	0.3056
p.T811S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	HRVQLGGLG	DEG_APCC_DBOX_1	0.3056
p.T811S	ACH-000797	Non-Cancerous	CCLE	HRVQLGGLG	DEG_APCC_DBOX_1	0.3056
p.A795S	ACH-000809	Esophageal Cancer	CCLE	HRVQLGGLG	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75420	GRB10-interacting GYF protein 1	DEG_APCC_DBOX_1	802:810	HRVQLGGLG	APC,CDC20,FZR1	0.8558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons