DegronMD

Uniprot ID: O75420

Source protein: GRB10-interacting GYF protein 1

Source gene: GIGYF1

Class: DEG_APCC_KENBOX_2

Location: 51:55

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9245

ASA_SCORE: 106.48

COIL: 0.861

CONS_SCORE: 0.3117

DSS_SCORE: 0.3529

HELIX: 0.088

FCONS_SCORE: 0.7494

RIG_SCORE: 0.8096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E59Q	TCGA-2Y-A9GW	LIHC	TCGA	VKENK	DEG_APCC_KENBOX_2	0.2222
p.E59Q	DO219511	LIHC	ICGC	VKENK	DEG_APCC_KENBOX_2	0.2222
p.E53D	TCGA-AA-3855	COAD	TCGA	VKENK	DEG_APCC_KENBOX_2	0.6758
p.E53D	DO10742	COAD	ICGC	VKENK	DEG_APCC_KENBOX_2	0.6758
p.N54S	TCGA-AP-A0LM	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	0.7069
p.N54S	DO43306	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	0.7069
p.E64K	TCGA-D1-A101	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	0.0833
p.E64K	DO43955	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	0.0833
p.V51I	TCGA-FI-A2EX	UCEC	TCGA	VKENK	DEG_APCC_KENBOX_2	0.5965
p.V51I	DO42352	UCEC	ICGC	VKENK	DEG_APCC_KENBOX_2	0.5965
p.LY49LH	DO220903	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	0
p.Y50H	DO220903	MELA	ICGC	VKENK	DEG_APCC_KENBOX_2	0.3056
p.L49V	DO46420	OV	ICGC	VKENK	DEG_APCC_KENBOX_2	0.2778
p.E44K	DO33224	PACA	ICGC	VKENK	DEG_APCC_KENBOX_2	0.1389
p.M46I	SIDM01280	Esophageal Carcinoma	GDSC	VKENK	DEG_APCC_KENBOX_2	0.1944
p.E59K	ACH-000279	Bone Cancer	CCLE	VKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14966	Ras-related protein Rab-7L1	DEG_APCC_KENBOX_2	156:160	VKENK	APC,CDC20,FZR1	0.8907	More...
O75420	GRB10-interacting GYF protein 1	DEG_APCC_KENBOX_2	51:55	VKENK	APC,CDC20,FZR1	0.9245	More...
P63128	Endogenous retrovirus group K member 9 Pol protein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.525	More...
P62684	Endogenous retrovirus group K member 113 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9925	More...
P63126	Endogenous retrovirus group K member 9 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.854	More...
P63130	Endogenous retrovirus group K member 7 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9428	More...
P63145	Endogenous retrovirus group K member 24 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8705	More...
P87889	Endogenous retrovirus group K member 10 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9753	More...
Q7LDI9	Endogenous retrovirus group K member 6 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8189	More...
Q9HDB9	Endogenous retrovirus group K member 5 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9912	More...
Q9YNA8	Endogenous retrovirus group K member 19 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9866	More...
P62683	Endogenous retrovirus group K member 21 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.8826	More...
P62685	Endogenous retrovirus group K member 8 Gag polyprotein	DEG_APCC_KENBOX_2	199:203	VKENK	APC,CDC20,FZR1	0.9243	More...
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_APCC_KENBOX_2	1107:1111	VKENK	APC,CDC20,FZR1	0.9176	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKENK

Degron related mutations and impact score

Drug responses associated with GIGYF1 mutations

All proteins holding degron of VKENK