DegronMD

Uniprot ID: Q9BXX2

Source protein: Ankyrin repeat domain-containing protein 30B

Source gene: ANKRD30B

Class: DEG_SCF_FBW7_1

Location: 378:383

E3 ligase: FBXW7

DEGRON score: 0.9051

ASA_SCORE: 83.6333

COIL: 0.7762

CONS_SCORE: 0.407

DSS_SCORE: 0.4264

HELIX: 0.1353

FCONS_SCORE: 0.7603

RIG_SCORE: 0.7602

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C374W	TCGA-27-1832	GBM	TCGA	VTPNKT	DEG_SCF_FBW7_1	0.2222
p.C374W	DO10912	GBM	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.2222
p.V385F	TCGA-AP-A0LM	UCEC	TCGA	VTPNKT	DEG_SCF_FBW7_1	0.2778
p.V385F	DO43306	UCEC	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.2778
p.E387G	TCGA-D1-A17U	UCEC	TCGA	VTPNKT	DEG_SCF_FBW7_1	0.2222
p.E387G	DO41887	UCEC	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.2222
p.E384K	TCGA-EE-A29E	SKCM	TCGA	VTPNKT	DEG_SCF_FBW7_1	0.3056
p.E384K	DO37831	SKCM	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.3056
p.A376T	TCGA-F7-A624	HNSC	TCGA	VTPNKT	DEG_SCF_FBW7_1	0.2778
p.A376T	DO44440	HNSC	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.2778
p.G377V	TCGA-ZJ-AAXU	CESC	TCGA	VTPNKT	DEG_SCF_FBW7_1	0.3056
p.G377V	DO219759	CESC	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.3056
p.E384D	DO50384	ESAD	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.3056
p.V375L	DO229045	LICA	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.P380S	DO229057	LICA	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.6752
p.V378L	DO23312	LINC	ICGC	VTPNKT	DEG_SCF_FBW7_1	0.5654
p.V375M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00845	Burkitt's Lymphoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00846	Cervical Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM01112	Osteosarcoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00878	Breast Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00907	Burkitt's Lymphoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00721	Small Cell Lung Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM01140	Ovarian Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.V375M	SIDM00628	Breast Carcinoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.25
p.T390I	SIDM00234	Other Solid Cancers	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.1389
p.T390I	ACH-002201	Cervical Cancer	CCLE	VTPNKT	DEG_SCF_FBW7_1	0.1389
p.T390I	TC-YIK	cervix	COSMIC	VTPNKT	DEG_SCF_FBW7_1	0.1389
p.T390A	SIDM00266	Ewing's Sarcoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.1389
p.T390A	ACH-002103	Bone Cancer	CCLE	VTPNKT	DEG_SCF_FBW7_1	0.1389
p.T390A	ES1	bone	COSMIC	VTPNKT	DEG_SCF_FBW7_1	0.1389
p.S369F	SIDM00417	Plasma Cell Myeloma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.0833
p.S369F	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.0833
p.S369F	ACH-000626	Myeloma	CCLE	VTPNKT	DEG_SCF_FBW7_1	0.0833
p.S369F	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	VTPNKT	DEG_SCF_FBW7_1	0.0833
p.T379I	SIDM01560	Rhabdomyosarcoma	GDSC	VTPNKT	DEG_SCF_FBW7_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPNKT

Degron related mutations and impact score

Drug responses associated with ANKRD30B mutations

All proteins holding degron of VTPNKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXX2	Ankyrin repeat domain-containing protein 30B	DEG_SCF_FBW7_1	378:383	VTPNKT	FBXW7	0.9051	More...