DegronMD

Uniprot ID: Q9BXX2

Source protein: Ankyrin repeat domain-containing protein 30B

Source gene: ANKRD30B

Class: LIG_APCC_ABBA_1

Location: 229:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7018

ASA_SCORE: 54.5333

COIL: 0.7812

CONS_SCORE: 0.3036

DSS_SCORE: 0.0494

HELIX: 0.1415

FCONS_SCORE: 0.8252

RIG_SCORE: 0.8997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G222S	TCGA-A5-A0G2	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	0.1389
p.G222S	DO41235	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.1389
p.V231I	TCGA-A5-A0G2	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	0.5965
p.V231I	TCGA-DF-A2KU	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	0.5965
p.V231I	DO223286	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.5965
p.V231I	DO41235	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.5965
p.V231I	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VDVFAE	LIG_APCC_ABBA_1	0.5965
p.V231I	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VDVFAE	LIG_APCC_ABBA_1	0.5965
p.G238V	TCGA-AJ-A3EL	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	0.2222
p.G238V	DO229008	LICA	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.2222
p.G238V	DO41542	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.2222
p.A241T	TCGA-AP-A1DK	UCEC	TCGA	VDVFAE	LIG_APCC_ABBA_1	0.1389
p.A241T	DO42033	UCEC	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.1389
p.D235G	DO234157	ESAD	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.3056
p.L225P	DO231078	LUSC	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.2222
p.E219D	DO228263	MALY	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.0556
p.A233T	DO229253	THCA	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.6028
p.H237R	DO229268	THCA	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.25
p.R243S	DO229208	THCA	ICGC	VDVFAE	LIG_APCC_ABBA_1	0.0833
p.V221D	SIDM01522	B-Lymphoblastic Leukemia	GDSC	VDVFAE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXX2	Ankyrin repeat domain-containing protein 30B	LIG_APCC_ABBA_1	229:234	VDVFAE	APC,CDC20,FZR1	0.7018	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons