DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ADSTT
Uniprot ID:
O75367
Source protein:
Core histone macro-H2A.1
Source gene:
MACROH2A1
Class:
DEG_SPOP_SBC_1
Location:
171:175
E3 ligase:
SPOP
DEGRON score:
0.946
ASA_SCORE:
82.6
COIL:
0.8392
CONS_SCORE:
0.4753
DSS_SCORE:
0.5199
HELIX:
0.0902
FCONS_SCORE:
0.9565
RIG_SCORE:
0.6377
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A171T
SIDM02059
Colorectal Carcinoma
GDSC
ADSTT
DEG_SPOP_SBC_1
0.7139
p.T175A
SIDM01146
Gastric Carcinoma
GDSC
ADSTT
DEG_SPOP_SBC_1
0.825
Drug responses associated with MACROH2A1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ADSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75367
Core histone macro-H2A.1
DEG_SPOP_SBC_1
171:175
ADSTT
SPOP
0.946
More...
O75367
Core histone macro-H2A.1
DEG_SPOP_SBC_1
171:175
ADSTT
SPOP
0.946
More...
Q3MIW9
Mucin-like protein 3
DEG_SPOP_SBC_1
143:147
ADSTT
SPOP
0.8151
More...
Q86VF2
Immunoglobulin-like and fibronectin type III domain-containing protein 1
DEG_SPOP_SBC_1
699:703
ADSTT
SPOP
0.9912
More...
Q96JG9
Zinc finger protein 469
DEG_SPOP_SBC_1
2782:2786
ADSTT
SPOP
0.6031
More...
Q9BXX2
Ankyrin repeat domain-containing protein 30B
DEG_SPOP_SBC_1
941:945
ADSTT
SPOP
0.998
More...