DegronMD

Uniprot ID: Q86VF2

Source protein: Immunoglobulin-like and fibronectin type III domain-containing protein 1

Source gene: IGFN1

Class: LIG_APCC_ABBA_1

Location: 423:428

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9941

ASA_SCORE: 72.1

COIL: 0.4045

CONS_SCORE: 0.4038

DSS_SCORE: 0.6314

HELIX: 0.0165

FCONS_SCORE: 1.1991

RIG_SCORE: 0.7274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q418R	DO229010	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1944
p.Q418R	DO229013	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1944
p.Q418R	DO229016	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1944
p.Q418R	DO229003	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1944
p.Q418R	DO229005	COCA	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1944
p.Q418R	DO51031	LAML	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1944
p.S435F	DO222749	MELA	ICGC	LDIYGE	LIG_APCC_ABBA_1	0.1389
p.S435F	ACH-000552	Colon/Colorectal Cancer	CCLE	LDIYGE	LIG_APCC_ABBA_1	0.1389
p.T437K	SW900	lung	COSMIC	LDIYGE	LIG_APCC_ABBA_1	0.0833
p.R415M	NCI-H292	lung	COSMIC	LDIYGE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VF2	Immunoglobulin-like and fibronectin type III domain-containing protein 1	LIG_APCC_ABBA_1	423:428	LDIYGE	APC,CDC20,FZR1	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons