DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: DEG_SCF_FBW7_1

Location: 2809:2814

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 80.3333

COIL: 0.9335

CONS_SCORE: 0.5846

DSS_SCORE: 0.8848

HELIX: 0.0383

FCONS_SCORE: 1.1295

RIG_SCORE: 0.5481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2803F	TCGA-DD-AADA	LIHC	TCGA	PTPDAS	DEG_SCF_FBW7_1	0.1667
p.A2813T	TCGA-DD-AADO	LIHC	TCGA	PTPDAS	DEG_SCF_FBW7_1	0.6028
p.K2819M	TCGA-OR-A5KB	ACC	TCGA	PTPDAS	DEG_SCF_FBW7_1	0.3056
p.P2809L	DO41572	UCEC	ICGC	PTPDAS	DEG_SCF_FBW7_1	0.6471
p.P2822S	DO41847	UCEC	ICGC	PTPDAS	DEG_SCF_FBW7_1	0.1111
p.S2816F	ACH-000799	Skin Cancer	CCLE	PTPDAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JG9	Zinc finger protein 469	DEG_SCF_FBW7_1	2809:2814	PTPDAS	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons