DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: LIG_APCC_ABBA_1

Location: 3033:3038

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9491

ASA_SCORE: 81.6333

COIL: 0.875

CONS_SCORE: 0.8151

DSS_SCORE: 0.3247

HELIX: 0.0315

FCONS_SCORE: 1.1058

RIG_SCORE: 0.7989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V3040M	TCGA-A6-6649	COAD	TCGA	LGPFED	LIG_APCC_ABBA_1	0.2778
p.P3040L	DO10140	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	0.2778
p.R3042C	DO10244	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	0.2222
p.R3042C	DO35442	PACA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.2222
p.R3042C	DO46877	RECA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.2222
p.R3042H	DO8642	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	0.2222
p.E3047G	DO8479	COAD	ICGC	LGPFED	LIG_APCC_ABBA_1	0.0833
p.T3044M	DO233163	GACA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.1667
p.T3044M	DO233887	GACA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.1667
p.G3030S	DO230940	LUSC	ICGC	LGPFED	LIG_APCC_ABBA_1	0.25
p.G3030S	DO224584	LUSC	ICGC	LGPFED	LIG_APCC_ABBA_1	0.25
p.G3034E	DO220879	MELA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.6087
p.C3028S	DO233383	RECA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.1944
p.P3033S	DO229456	SKCA	ICGC	LGPFED	LIG_APCC_ABBA_1	0.6752
p.P3040S	DO41572	UCEC	ICGC	LGPFED	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JG9	Zinc finger protein 469	LIG_APCC_ABBA_1	3033:3038	LGPFED	APC,CDC20,FZR1	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons