DegronMD

Uniprot ID: Q96JG9

Source protein: Zinc finger protein 469

Source gene: ZNF469

Class: DEG_SCF_FBW7_2

Location: 3295:3302

E3 ligase: FBXW7

DEGRON score: 0.8989

ASA_SCORE: 85.8625

COIL: 0.7919

CONS_SCORE: 0.8119

DSS_SCORE: 0.5579

HELIX: 0.1429

FCONS_SCORE: 1.0676

RIG_SCORE: 0.684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3305S	DO49009	CESC	ICGC	LQATPVHE	DEG_SCF_FBW7_2	0.3611
p.T3307K	DO227982	COCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	0.1944
p.A3286V	DO234226	ESAD	ICGC	LQATPVHE	DEG_SCF_FBW7_2	0.0833
p.G3300S	DO229208	THCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	0.6993
p.D3298N	DO229240	THCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	0.6932
p.A3286S	DO229250	THCA	ICGC	LQATPVHE	DEG_SCF_FBW7_2	0.0833
p.A3289D	SIDM02018	Colorectal Carcinoma	GDSC	LQATPVHE	DEG_SCF_FBW7_2	0.1667
p.H3301Y	ACH-000966	Ovarian Cancer	CCLE	LQATPVHE	DEG_SCF_FBW7_2	0.6118
p.A3303V	ACH-000988	Endometrial/Uterine Cancer	CCLE	LQATPVHE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JG9	Zinc finger protein 469	DEG_SCF_FBW7_2	3295:3302	LQATPVHE	FBXW7	0.8989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons