DegronMD - P78312(FAM193A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P489L	TCGA-37-4130	LUSC	TCGA	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1667
p.P489L	DO228187	LICA	ICGC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1667
p.P489L	DO26490	LUSC	ICGC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1667
p.P489L	SIDM00983	Bladder Carcinoma	GDSC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1667
p.P489L	647-V	urinary tract	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1667
p.E974Q	TCGA-39-5022	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1944
p.E974Q	DO27604	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1944
p.R871Q	TCGA-49-6767	LUAD	TCGA	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	TCGA-AJ-A3OL	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	TCGA-HU-A4G9	STAD	TCGA	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	DO23586	LUAD	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	DO47789	STAD	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	DO43001	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	SIDM01062	Breast Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.R871Q	HDQ-P1	breast	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.E977K	TCGA-61-1998	OV	TCGA	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.2778
p.E977K	DO28813	OV	ICGC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.2778
p.H874Y	TCGA-AJ-A3EK	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1111
p.H874Y	DO41584	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1111
p.D295N	TCGA-AJ-A3TW	UCEC	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1944
p.D295N	DO43723	UCEC	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1944
p.P278S	TCGA-AP-A1DK	UCEC	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1667
p.P278S	DO42033	UCEC	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1667
p.N970S	TCGA-CD-A4MH	STAD	TCGA	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.0833
p.N970S	DO47751	STAD	ICGC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.0833
p.A288T	TCGA-CV-A461	HNSC	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.6028
p.A288T	DO49058	HNSC	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.6028
p.P300Q	TCGA-D3-A2J6	SKCM	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.0556
p.P300Q	DO37901	SKCM	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.0556
p.P474H	TCGA-D5-6927	COAD	TCGA	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.2778
p.P474H	DO10332	COAD	ICGC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.2778
p.S485I	TCGA-DF-A2KU	UCEC	TCGA	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.2778
p.S485I	DO223286	UCEC	ICGC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.2778
p.E404K	TCGA-DK-AA6R	BLCA	TCGA	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.E404K	DO219006	BLCA	ICGC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.P399T	TCGA-EE-A2M5	SKCM	TCGA	PPSY	ITCH	395:398	Mutation rewiring degron network	0.3056
p.P399T	DO37425	SKCM	ICGC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.3056
p.E859K	TCGA-EE-A2MM	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.E859K	DO229052	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.E859K	DO222678	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.E859K	DO37770	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.L852F	TCGA-G3-A25Z	LIHC	TCGA	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0556
p.L852F	DO23078	LIHC	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0556
p.R469H	TCGA-G4-6304	COAD	TCGA	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.R469H	DO10639	COAD	ICGC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.R469H	SIDM00352	Ovarian Carcinoma	GDSC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.R469H	RMG-I	ovary	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.S287L	DO233259	GACA	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.7667
p.R867H	DO233882	GACA	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.3056
p.S389G	DO228947	LICA	ICGC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1667
p.R873S	DO229009	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1389
p.Q402L	DO231047	LUSC	ICGC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.2222
p.S858F	DO218863	SKCA	ICGC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.S858F	SIDM00272	Breast Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.S858F	MDA-MB-453	breast	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.S985F	SIDM01307	Colorectal Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation blocking phosphorylation signal	0.7222
p.H984R	SIDM00917	Acute Myeloid Leukemia	GDSC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.H984R	CESS	haematopoietic and lymphoid tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.3056
p.P481R	SIDM00942	Oral Cavity Carcinoma	GDSC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.6401
p.P481R	CAL-33	upper aerodigestive tract	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.6401
p.A288V	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.5825
p.A288V	NCI-H1563	lung	COSMIC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.5825
p.E387G	SIDM01045	Endometrial Carcinoma	GDSC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1111
p.E387G	EN	endometrium	COSMIC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1111
p.G971C	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1111
p.G971C	KYSE-450	oesophagus	COSMIC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.1111
p.S405I	ACH-000636	Leukemia	CCLE	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.S405I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	395:398	Mutation rewiring degron network	0.1389
p.R491H	ACH-000719	Ovarian Cancer	CCLE	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1111
p.R491H	RMG-I	ovary	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1111
p.G993C	ACH-000865	Esophageal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.0556
p.G993C	KYSE-450	oesophagus	COSMIC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.0556
p.V864I	ACH-000867	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7076
p.V864I	ChaGo-K-1	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7076
p.R869M	ACH-000924	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.R869M	NCI-H2172	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.R869S	ACH-000924	Lung Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.R869S	NCI-H2172	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.D866N	ACH-000937	Leukemia	CCLE	PVSST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.6932
p.P281S	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.25
p.P281S	HCT-116	large intestine	COSMIC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.25
p.T467I	ACH-000985	Colon/Colorectal Cancer	CCLE	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0833
p.T467I	LS-411N	large intestine	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0833
p.I858L	ACH-001498	Lymphoma	CCLE	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.I858L	Farage	haematopoietic and lymphoid tissue	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.P985S	ACH-001982	Metastasis	CCLE	PETSS	DEG_SPOP_SBC_1	979:983	Mutation blocking phosphorylation signal	0.7222
p.V865I	ACH-002247	Non-Cancerous	CCLE	PVSST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7076
p.V865I	IM-9	haematopoietic and lymphoid tissue	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7076
p.H468Y	ACH-002256	Leukemia	CCLE	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1111
p.H468Y	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1111
p.P395L	LU-134-A	lung	COSMIC	PPSY	ITCH	395:398	Mutation altering degron motif	0.7582
p.P395L	GB-1	central nervous system	COSMIC	PPSY	ITCH	395:398	Mutation altering degron motif	0.7582
p.P395L	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	395:398	Mutation altering degron motif	0.7582
p.P395L	KGN	ovary	COSMIC	PPSY	ITCH	395:398	Mutation altering degron motif	0.7582
p.M490I	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.S288L	EVSA-T	breast	COSMIC	DSGSAPT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.7667
p.A469T	Farage	haematopoietic and lymphoid tissue	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.P869A	SW1271	lung	COSMIC	PVSST	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.25
p.A970D	CW-2	large intestine	COSMIC	PETSS	DEG_SPOP_SBC_1	979:983	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM193A

UniProt ID: P78312

Entrez ID: 8603

Protein name: Protein FAM193A (Protein IT14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM193A in