DegronMD

Uniprot ID: P78312

Source protein: Protein FAM193A

Source gene: FAM193A

Class: DEG_SPOP_SBC_1

Location: 979:983

E3 ligase: SPOP

DEGRON score: 0.9825

ASA_SCORE: 95.68

COIL: 0.925

CONS_SCORE: 0.5291

DSS_SCORE: 0.8556

HELIX: 0.0482

FCONS_SCORE: 1.0729

RIG_SCORE: 0.5205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E974Q	TCGA-39-5022	LUSC	TCGA	PETSS	DEG_SPOP_SBC_1	0.1944
p.E974Q	DO27604	LUSC	ICGC	PETSS	DEG_SPOP_SBC_1	0.1944
p.E977K	TCGA-61-1998	OV	TCGA	PETSS	DEG_SPOP_SBC_1	0.2778
p.E977K	DO28813	OV	ICGC	PETSS	DEG_SPOP_SBC_1	0.2778
p.N970S	TCGA-CD-A4MH	STAD	TCGA	PETSS	DEG_SPOP_SBC_1	0.0833
p.N970S	DO47751	STAD	ICGC	PETSS	DEG_SPOP_SBC_1	0.0833
p.S985F	SIDM01307	Colorectal Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.7222
p.H984R	SIDM00917	Acute Myeloid Leukemia	GDSC	PETSS	DEG_SPOP_SBC_1	0.3056
p.H984R	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	PETSS	DEG_SPOP_SBC_1	0.3056
p.G971C	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	0.1111
p.G971C	KYSE-450	oesophagus	COSMIC	PETSS	DEG_SPOP_SBC_1	0.1111
p.G993C	ACH-000865	Esophageal Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	0.0556
p.G993C	KYSE-450	oesophagus	COSMIC	PETSS	DEG_SPOP_SBC_1	0.0556
p.P985S	ACH-001982	Metastasis	CCLE	PETSS	DEG_SPOP_SBC_1	0.7222
p.A970D	CW-2	large_intestine	COSMIC	PETSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2431:2435	PETSS	SPOP	0.9627	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	140:144	PETSS	SPOP	0.963	More...
P49116	Nuclear receptor subfamily 2 group C member 2	DEG_SPOP_SBC_1	69:73	PETSS	SPOP	0.9587	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	444:448	PETSS	SPOP	0.5922	More...
Q5JXC2	Migration and invasion-inhibitory protein	DEG_SPOP_SBC_1	55:59	PETSS	SPOP	0.7541	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SPOP_SBC_1	77:81	PETSS	SPOP	0.8068	More...
Q8IYB4	PEX5-related protein	DEG_SPOP_SBC_1	161:165	PETSS	SPOP	0.8276	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	1634:1638	PETSS	SPOP	0.7934	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2775:2779	PETSS	SPOP	0.9491	More...
Q99504	Eyes absent homolog 3	DEG_SPOP_SBC_1	38:42	PETSS	SPOP	0.9647	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	572:576	PETSS	SPOP	0.5145	More...
Q9Y5E8	Protocadherin beta-15	DEG_SPOP_SBC_1	143:147	PETSS	SPOP	0.7195	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	DEG_SPOP_SBC_1	269:273	PETSS	SPOP	0.866	More...
P78312	Protein FAM193A	DEG_SPOP_SBC_1	979:983	PETSS	SPOP	0.9825	More...
P0C874	Spermatogenesis-associated protein 31D3	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.6572	More...
Q5T1A1	DC-STAMP domain-containing protein 2	DEG_SPOP_SBC_1	739:743	PETSS	SPOP	0.9843	More...
Q6ZQQ2	Spermatogenesis-associated protein 31D1	DEG_SPOP_SBC_1	789:793	PETSS	SPOP	0.8868	More...
Q6ZUB0	Spermatogenesis-associated protein 31D4	DEG_SPOP_SBC_1	786:790	PETSS	SPOP	0.8838	More...
Q9ULG3	Uncharacterized protein CFAP92	DEG_SPOP_SBC_1	276:280	PETSS	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETSS

Degron related mutations and impact score

Drug responses associated with FAM193A mutations

All proteins holding degron of PETSS