DegronMD - Q8IZF0(NALCN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R694C	TCGA-44-8117	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694C	TCGA-AZ-4682	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694C	DO8562	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694C	DO24028	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694C	DO35345	PACA	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.T684I	TCGA-95-7567	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7078
p.T684I	DO25564	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7078
p.P682L	TCGA-A5-A0G2	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7582
p.P682L	DO41235	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7582
p.S1648L	TCGA-AP-A056	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.0556
p.S1648L	DO43971	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.0556
p.L1643M	TCGA-AP-A059	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.L1643M	DO41361	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.P1634T	TCGA-AP-A059	UCEC	TCGA	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7031
p.P1634T	DO41361	UCEC	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7031
p.T1646M	TCGA-BR-6453	STAD	TCGA	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.T1646M	DO38543	STAD	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.D673N	TCGA-CK-4951	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.D673N	DO10582	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.R694H	TCGA-DI-A0WH	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694H	DO228138	PBCA	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694H	DO43843	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.C676S	TCGA-E8-A242	THCA	TCGA	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1667
p.C676S	DO40051	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1667
p.P1634L	TCGA-ER-A193	SKCM	TCGA	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7582
p.P1634L	DO47368	SKCM	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7582
p.L1643P	TCGA-L5-A8NK	ESCA	TCGA	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1944
p.N1630K	DO234384	ESAD	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.2222
p.S692P	DO233144	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1667
p.S1638N	DO233888	GACA	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7069
p.S1638N	SIDM00933	Breast Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7069
p.S1638N	ACH-000856	Breast Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7069
p.S1638N	CAL-51	breast	COSMIC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation altering degron motif	0.7069
p.Q672K	DO228976	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0556
p.S1631R	DO229038	LICA	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.T1646K	DO23328	LINC	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.D690N	DO52686	MALY	ICGC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2222
p.D690N	SIDM00193	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2222
p.D690N	ACH-000991	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2222
p.D690N	SNU-81	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2222
p.Q1641K	DO46382	OV	ICGC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.S1631N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.S1631N	ACH-000866	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.S1631N	NCI-H1048	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.25
p.R694S	SIDM00616	Hepatocellular Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694S	ACH-000476	Liver Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694S	JHH-4	liver	COSMIC	PTTSS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.T1646S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.T1646S	ACH-000916	Lung Cancer	CCLE	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111
p.T1646S	NCI-H1573	lung	COSMIC	PETSS	DEG_SPOP_SBC_1	1634:1638	Mutation rewiring degron network	0.1111

Kaplan plot for NALCN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NALCN

UniProt ID: Q8IZF0

Entrez ID: 259232

Protein name: Sodium leak channel NALCN (CanIon) (Sodium leak channel non-selective protein) (Voltage gated channel-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NALCN in