DegronMD

Uniprot ID: Q8IZF0

Source protein: Sodium leak channel NALCN

Source gene: NALCN

Class: DEG_SPOP_SBC_1

Location: 682:686

E3 ligase: SPOP

DEGRON score: 0.8231

ASA_SCORE: 87.74

COIL: 0.9348

CONS_SCORE: 0.2959

DSS_SCORE: 0.3156

HELIX: 0.0456

FCONS_SCORE: 1.0866

RIG_SCORE: 0.6566

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P682L	TCGA-A5-A0G2	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7582
p.P682L	DO41235	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7582
p.T684I	TCGA-95-7567	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7078
p.T684I	DO25564	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7078
p.D690N	DO52686	MALY	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.D690N	SIDM00193	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.D690N	ACH-000991	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.2222
p.D690N	SNU-81	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.C676S	TCGA-E8-A242	THCA	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1667
p.C676S	DO40051	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.S692P	DO233144	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.R694C	TCGA-44-8117	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694C	TCGA-AZ-4682	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694C	DO8562	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694C	DO24028	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694C	DO35345	PACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694H	TCGA-DI-A0WH	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694H	DO228138	PBCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694H	DO43843	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694S	SIDM00616	Hepatocellular Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694S	ACH-000476	Liver Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R694S	JHH-4	liver	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.D673N	TCGA-CK-4951	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.0833
p.D673N	DO10582	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.Q672K	DO228976	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 25 entries

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Drug responses associated with NALCN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PTTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...

Showing 1 to 19 of 19 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with NALCN mutations

All proteins holding degron of PTTSS